Manteia - Molecule gene

ENSMUSG00000015843

Mus musculus

Features

Gene ID:	ENSMUSG00000015843

Biological name :	Rxrg

Synonyms :	P28705 / Retinoic acid receptor RXR-gamma / Rxrg

Possible biological names infered from orthology :	P48443 / retinoid X receptor gamma

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	H2.3
Gene start:	167598384
Gene end:	167639623

Corresponding Affymetrix probe sets:	10351430 (MoGene1.0st) 1418782_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000107017 Ensembl peptide - ENSMUSP00000015987 Ensembl peptide - ENSMUSP00000107011 Ensembl peptide - ENSMUSP00000107015 NCBI entrez gene - 20183 See in Manteia. MGI - MGI:98216 RefSeq - NM_001159731 RefSeq - NM_009107 RefSeq Peptide - NP_001153203 RefSeq Peptide - NP_033133 swissprot - E9Q9V9 swissprot - P28705 Ensembl - ENSMUSG00000015843

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rxrgb	ENSDARG00000004697	Danio rerio
RXRG	ENSGALG00000040730	Gallus gallus
RXRG	ENSG00000143171	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rxra / P28700 / retinoid X receptor alpha / P19793*	ENSMUSG00000015846	70
Rxrb / P28704 / retinoid X receptor beta / P28702*	ENSMUSG00000039656	64
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*	ENSMUSG00000030551	33
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*	ENSMUSG00000017950	32
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*	ENSMUSG00000069171	32
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*	ENSMUSG00000017688	31
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*	ENSMUSG00000002393	31
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*	ENSMUSG00000005897	30
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*	ENSMUSG00000005893	30
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*	ENSMUSG00000032292	28
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*	ENSMUSG00000019803	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR000003	Retinoid X receptor/HNF4
IPR000536	Nuclear hormone receptor, ligand-binding domain
IPR001628	Zinc finger, nuclear hormone receptor-type
IPR001723	Nuclear hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR021780	Nuclear/hormone receptor activator site AF-1
IPR035500	Nuclear hormone receptor-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0043401	steroid hormone mediated signaling pathway	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
biological_process	GO:0048384	retinoic acid receptor signaling pathway	IDA
biological_process	GO:0051289	protein homotetramerization	IDA
biological_process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	IDA
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0003707	steroid hormone receptor activity	IEA
molecular_function	GO:0004886	9-cis retinoic acid receptor activity	IDA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Nuclear Receptor transcription pathway

Signaling by Retinoic Acid

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ank1^RBC2/Ank1^RBC2 Genetic Background: involves: 129S1/Sv * BALB/c
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh,Serping1^Gt1Aed/Serping1^Gt1Aed Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002822	catalepsy	"a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ank1^RBC2/Ank1^RBC2 Genetic Background: involves: 129S1/Sv * BALB/c
MP:0004037	increased muscle relaxation	"greater than the normal ability of the muscle to lengthen following contractions or increase in the ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Ank1^RBC2/Ank1^RBC2 Genetic Background: involves: 129S1/Sv * BALB/c
MP:0004077	abnormal striatum morphology	"malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Ank1^RBC2/Ank1^RBC2 Genetic Background: involves: 129S1/Sv * BALB/c Allelic Composition: Rxrg^tm2Ysa/Rxrg^tm2Ysa Genetic Background: involves: C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000004885	Crabp2 / P22935 / Cellular retinoic acid-binding protein 2 / P29373*	/ reaction / complex
ENSMUSG00000001288	Rarg / P18911 / Retinoic acid receptor gamma / P13631*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr