ENSMUSG00000002393


Mus musculus

Features
Gene ID: ENSMUSG00000002393
  
Biological name :Nr2f6
  
Synonyms : Nr2f6 / Nuclear receptor subfamily 2 group F member 6 / P43136
  
Possible biological names infered from orthology : P10588
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 71374123
Gene end: 71381960
  
Corresponding Affymetrix probe sets: 10579479 (MoGene1.0st)   1460647_a_at (Mouse Genome 430 2.0 Array)   1460648_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002466
Ensembl peptide - ENSMUSP00000116498
Ensembl peptide - ENSMUSP00000121648
NCBI entrez gene - 13864     See in Manteia.
MGI - MGI:1352453
RefSeq - XM_006509553
RefSeq - NM_010150
RefSeq Peptide - NP_034280
swissprot - F6Q454
swissprot - P43136
swissprot - F7DC78
Ensembl - ENSMUSG00000002393
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2f6aENSDARG00000003607Danio rerio
 nr2f6bENSDARG00000003165Danio rerio
 NR2F6ENSGALG00000043010Gallus gallus
 NR2F6ENSG00000160113Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*ENSMUSG0000003055166
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*ENSMUSG0000006917165
Rxra / P28700 / retinoid X receptor alpha / P19793*ENSMUSG0000001584638
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*ENSMUSG0000003229237
Rxrb / P28704 / retinoid X receptor beta / P28702*ENSMUSG0000003965636
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*ENSMUSG0000001584336
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*ENSMUSG0000001795035
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*ENSMUSG0000000589335
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*ENSMUSG0000001980334
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*ENSMUSG0000000589734
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*ENSMUSG0000001768832


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003068  Transcription factor COUP
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

 MP:0005447 abnormal synaptic norepinephrine release "aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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