ENSMUSG00000030551


Mus musculus

Features
Gene ID: ENSMUSG00000030551
  
Biological name :Nr2f2
  
Synonyms : Nr2f2 / nuclear receptor subfamily 2, group F, member 2 / P43135
  
Possible biological names infered from orthology : P24468
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: C
Gene start: 70351944
Gene end: 70366735
  
Corresponding Affymetrix probe sets: 10564527 (MoGene1.0st)   1416158_at (Mouse Genome 430 2.0 Array)   1416159_at (Mouse Genome 430 2.0 Array)   1416160_at (Mouse Genome 430 2.0 Array)   1431237_at (Mouse Genome 430 2.0 Array)   1436475_at (Mouse Genome 430 2.0 Array)   1444229_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147190
Ensembl peptide - ENSMUSP00000032768
Ensembl peptide - ENSMUSP00000086993
NCBI entrez gene - 11819     See in Manteia.
MGI - MGI:1352452
RefSeq - XM_006540578
RefSeq - NM_009697
RefSeq - NM_183261
RefSeq Peptide - NP_033827
RefSeq Peptide - NP_899084
swissprot - A0A140LJF1
swissprot - P43135
swissprot - D3YYP4
swissprot - Q3UST6
Ensembl - ENSMUSG00000030551
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2f2ENSDARG00000040926Danio rerio
 NR2F2ENSGALG00000007000Gallus gallus
 NR2F2ENSG00000185551Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*ENSMUSG0000006917188
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*ENSMUSG0000000239362
Rxra / P28700 / retinoid X receptor alpha / P19793*ENSMUSG0000001584639
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*ENSMUSG0000001584337
Rxrb / P28704 / retinoid X receptor beta / P28702*ENSMUSG0000003965636
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*ENSMUSG0000000589336
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*ENSMUSG0000003229236
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*ENSMUSG0000000589734
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*ENSMUSG0000001980333
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*ENSMUSG0000001795032
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*ENSMUSG0000001768830


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003068  Transcription factor COUP
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001764 neuron migration IDA
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001945 lymph vessel development IEP
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0009956 radial pattern formation IMP
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0030900 forebrain development IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0060173 limb development IMP
 biological_processGO:0060674 placenta blood vessel development IMP
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 biological_processGO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nr2f2tm1Tsa/Nr2f2+
Genetic Background: either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002636 delayed vaginal opening "the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004785 abnormal posterior cardinal vein morphology "any structural anomaly of the two paired veins draining the caudal part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008959 abnormal spongiotrophoblast cell morphology "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0009020 prolonged metestrus "increase in the length of the metestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0009021 absent estrus "absence or failure of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0009085 abnormal uterine horn morphology "any structural anomaly of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet; uterine horns are anterior Mullerian duct-derived structures" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0009089 short uterine horn "length reduction or truncation of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010198 decreased lymphatic vessel endothelial cell number "reduced number of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010780 abnormal stomach smooth muscle circular layer morphology "any structural anomaly of the middle layer of the muscularis; it is continuous with the circular layer of the esophagus, but is absent in the fundus and lies concentric to the longitudinal axis of the stomach; the circular layer is normally tonically constricted forming a functional pyloric sphincter, which controls the movement of chyme into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0010785 abnormal stomach pyloric region morphology "any structural anomaly of the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nr2f2tm1Tsa/Nr2f2+
Genetic Background: either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2tm3(cre)Bhr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Rbpjtm1Hon/Rbpjtm1Hon,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011389 absent optic disc "absence of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0012535 abnormal optic fissure closure "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [MGI:anna]
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Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0013575 abnormal forestomach-glandular stomach junction morphology "any structural anomaly of the distinct low fold of tissue that separates the non-glandular area of the stomach (forestomach) from the glandular stomach; the limiting ridge extends circumferentially from the large curvature of the stomach to the small curvature, just below the esophagus; at the esophagus, the course of the limiting ridge bends into a U-shape and almost surrounds the esophageal opening" [http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CCUQFjAB&url=http%3A%2F%2Fjournals.usamvcluj.ro%2Findex.php%2Fveterinary%2Farticle%2Fdownload%2F5889%2F5384&ei=nQ61VJvFEMuQyASZpYGgCw&usg=AFQjCNHtPvbkRJR7v3Jh2Ht2z-s9qVBLGA&bvm=bv.83339334,d.aWw&cad=rja, MGI:anna]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

 MP:0013576 small forestomach "reduced size of the distinct rodent non-glandular region of the stomach which is demarcated from the glandular stomach by the limiting ridge (margo plicatus)" [MGI:Anna]
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Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: B6.129S-Col4a1deltaex40

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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