ENSMUSG00000032292


Mus musculus

Features
Gene ID: ENSMUSG00000032292
  
Biological name :Nr2e3
  
Synonyms : Nr2e3 / Photoreceptor-specific nuclear receptor / Q9QXZ7
  
Possible biological names infered from orthology : nuclear receptor subfamily 2 group E member 3 / Q9Y5X4
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 59942771
Gene end: 59960659
  
Corresponding Affymetrix probe sets: 10594188 (MoGene1.0st)   1423631_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034831
NCBI entrez gene - 23958     See in Manteia.
MGI - MGI:1346317
RefSeq - XM_011242742
RefSeq - NM_013708
RefSeq - XM_006511149
RefSeq - XM_006511150
RefSeq Peptide - NP_038736
swissprot - Q543C7
swissprot - Q9QXZ7
Ensembl - ENSMUSG00000032292
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2e3ENSDARG00000045904Danio rerio
 NR2E3ENSGALG00000002093Gallus gallus
 NR2E3ENSG00000278570Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*ENSMUSG0000001980342
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*ENSMUSG0000006917137
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*ENSMUSG0000003055137
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*ENSMUSG0000000239336
Rxra / P28700 / retinoid X receptor alpha / P19793*ENSMUSG0000001584635
Rxrb / P28704 / retinoid X receptor beta / P28702*ENSMUSG0000003965633
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*ENSMUSG0000001584333
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*ENSMUSG0000001795031
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*ENSMUSG0000000589731
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*ENSMUSG0000000589331
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*ENSMUSG0000001768829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003068  Transcription factor COUP
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045872 positive regulation of rhodopsin gene expression IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

Allelic Composition: Nr2e3tm1Dgen/Nr2e3tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0008516 disorganized retinal outer nuclear layer "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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