ENSMUSG00000039656


Mus musculus

Features
Gene ID: ENSMUSG00000039656
  
Biological name :Rxrb
  
Synonyms : P28704 / retinoid X receptor beta / Rxrb
  
Possible biological names infered from orthology : P28702
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34031812
Gene end: 34038393
  
Corresponding Affymetrix probe sets: 10444137 (MoGene1.0st)   1416990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133661
Ensembl peptide - ENSMUSP00000036585
Ensembl peptide - ENSMUSP00000112311
Ensembl peptide - ENSMUSP00000133775
Ensembl peptide - ENSMUSP00000134299
NCBI entrez gene - 20182     See in Manteia.
MGI - MGI:98215
RefSeq - NM_001205215
RefSeq - NM_001205214
RefSeq - NM_001205216
RefSeq - NM_011306
RefSeq Peptide - NP_035436
RefSeq Peptide - NP_001192143
RefSeq Peptide - NP_001192144
RefSeq Peptide - NP_001192145
swissprot - Q3TWJ1
swissprot - G3UXP8
swissprot - Q8VCR0
swissprot - G3UZ09
swissprot - P28704
Ensembl - ENSMUSG00000039656
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxrbaENSDARG00000078954Danio rerio
 rxrbbENSDARG00000002006Danio rerio
 RXRBENSG00000204231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rxra / P28700 / retinoid X receptor alpha / P19793*ENSMUSG0000001584661
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*ENSMUSG0000001584357
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*ENSMUSG0000001795029
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*ENSMUSG0000001768829
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*ENSMUSG0000003055129
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*ENSMUSG0000006917128
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*ENSMUSG0000000239327
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*ENSMUSG0000000589726
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*ENSMUSG0000000589326
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*ENSMUSG0000003229225
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*ENSMUSG0000001980322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000003  Retinoid X receptor/HNF4
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR021780  Nuclear/hormone receptor activator site AF-1
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001893 maternal placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048384 retinoic acid receptor signaling pathway IDA
 biological_processGO:0055012 ventricular cardiac muscle cell differentiation IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IGI
 biological_processGO:0071300 cellular response to retinoic acid IDA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity ISO
 molecular_functionGO:0004886 9-cis retinoic acid receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IGI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001247 dermal cysts "abnormal membranous sacs appearing in the dermis" [J:53379]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapk7tm1Kda/Mapk7tm1Kda
Genetic Background: involves: 129S6/SvEvTac

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2+,Rxrbtm1Mma/Rxrb+
Genetic Background: involves: 129 * C57BL/6

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1.1Pcn/Rxratm1.1Pcn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004971 dermal hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the dermal layer of the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010584 abnormal conotruncus septation "anomaly in the process in which the conotruncus separates into the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010706 ventral rotation of lens "a circular shift toward the ventral pole in the position of the equator of the lens relative to the optic nerve exit point" [PMID:7923367]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010716 coloboma of the optic disc "congenital defect of the optic disc in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pou3f4tm1Cren/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012802 increased rhombomere 5 size "increased size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order " [MGI:anna]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013269 third pharyngeal arch hypoplasia "underdevelopment or reduced size of the third pharyngeal arch, usually due to reduced cell number" [MGI:anna]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030335 absent third pharyngeal arch artery "failure to develop or absence of the third pharyngeal arch artery" [MGI:anna]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004885 Crabp2 / P22935 / Cellular retinoic acid-binding protein 2 / P29373*  / complex / reaction
 ENSMUSG00000017491 Rarb / P22605 / retinoic acid receptor, beta / P10826*  / complex






 

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