ENSMUSG00000019803


Mus musculus

Features
Gene ID: ENSMUSG00000019803
  
Biological name :Nr2e1
  
Synonyms : Nr2e1 / nuclear receptor subfamily 2, group E, member 1 / Q64104
  
Possible biological names infered from orthology : Q9Y466
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B2
Gene start: 42561963
Gene end: 42583632
  
Corresponding Affymetrix probe sets: 10368907 (MoGene1.0st)   1434921_at (Mouse Genome 430 2.0 Array)   1457289_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019938
Ensembl peptide - ENSMUSP00000101137
NCBI entrez gene - 21907     See in Manteia.
MGI - MGI:1100526
RefSeq - XM_006512701
RefSeq - NM_152229
RefSeq Peptide - NP_689415
swissprot - Q3UXE8
swissprot - Q64104
swissprot - Q78ZM1
Ensembl - ENSMUSG00000019803
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr2e1ENSDARG00000017107Danio rerio
 NR2E1ENSGALG00000015305Gallus gallus
 NR2E1ENSG00000112333Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*ENSMUSG0000003229243
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*ENSMUSG0000006917136
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*ENSMUSG0000000239335
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*ENSMUSG0000003055135
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*ENSMUSG0000000589734
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*ENSMUSG0000000589333
Rxra / P28700 / retinoid X receptor alpha / P19793*ENSMUSG0000001584632
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*ENSMUSG0000001584331
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*ENSMUSG0000001795031
Rxrb / P28704 / retinoid X receptor beta / P28702*ENSMUSG0000003965630
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*ENSMUSG0000001768830


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003068  Transcription factor COUP
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0002118 aggressive behavior IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008347 glial cell migration IMP
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0021764 amygdala development IMP
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0021819 layer formation in cerebral cortex IMP
 biological_processGO:0021872 forebrain generation of neurons IMP
 biological_processGO:0021895 cerebral cortex neuron differentiation IMP
 biological_processGO:0021960 anterior commissure morphogenesis IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048712 negative regulation of astrocyte differentiation IMP
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:0051128 regulation of cellular component organization IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060164 regulation of timing of neuron differentiation IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0090049 regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IMP
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 biological_processGO:2000648 positive regulation of stem cell proliferation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1tm2Gsc/Nr2e1tm2Gsc,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Nr2e1tm2Gsc/Nr2e1tm2Gsc,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1tm2Gsc/Nr2e1tm2Gsc,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0001357 increased aggression to humans "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward humans" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: msp4/msp4,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr2e1tm2Gsc/Nr2e1tm2Gsc,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0002061 aggression-related behavior "domineering, assaultive or forceful physical action" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: msp4/msp4,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Hprttm86(NR2E1,bEMS223)Ems/Y,Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0004166 abnormal limbic system morphology "any malformation or absence of any of a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory; these structures act together to control the endocrine system and the autonomic nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0004171 abnormal pallium development "anomaly in the progression of the formation of the roof region of the telencephalon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Hprttm86(NR2E1,bEMS223)Ems/Y,Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0005267 abnormal olfactory cortex morphology "anomalous structure of piriform cortex, part of the olfactory tract, which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83884]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

 MP:0005655 increased aggression "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0006219 optic nerve degeneration "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0006300 abnormal entorhinal cortex morphology "any structural anomaly of the structure in the anterior parahippocampus that lies forward of the parahippocampal cortex and immediately medial to the perirhinal cortex, bounded superiorly by the hippocampus and inferiorly by the collateral sulcus" [brs:Beverly Richards-Smith_IMSR Curator]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm2Gsc/Nr2e1tm2Gsc,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008431 abnormal short-term spatial reference memory "anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encouter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008457 abnormal cortical intermediate zone morphology "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0008509 disorganized retinal ganglion layer "derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

 MP:0008512 disorganized retinal inner nuclear layer "derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

 MP:0008516 disorganized retinal outer nuclear layer "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Hprttm86(NR2E1,bEMS223)Ems/Y,Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Nr2e1tm1Rev/Nr2e1tm1Rev,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0020388 decreased radial glial cell number "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25698753]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0020537 decreased subiculum size "decreased size of the subiculum" [MGI:smb]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004263 Atn1 / O35126 / Atrophin-1 / P54259*  / complex






 

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