ENSMUSG00000004263


Mus musculus

Features
Gene ID: ENSMUSG00000004263
  
Biological name :Atn1
  
Synonyms : Atn1 / Atrophin-1 / O35126
  
Possible biological names infered from orthology : P54259
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124742544
Gene end: 124756524
  
Corresponding Affymetrix probe sets: 10547795 (MoGene1.0st)   1421149_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123560
Ensembl peptide - ENSMUSP00000085695
NCBI entrez gene - 13498     See in Manteia.
MGI - MGI:104725
RefSeq - NM_007881
RefSeq Peptide - NP_031907
swissprot - D3YYE6
swissprot - O35126
Ensembl - ENSMUSG00000004263
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atn1ENSDARG00000092067Danio rerio
 ATN1ENSGALG00000014554Gallus gallus
 ATN1ENSG00000111676Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35126 / Gm45234 / predicted gene 45234 / ATN1* / P54259* / atrophin 1*ENSMUSG00000107478100
Rere / Q80TZ9 / Arginine-glutamic acid dipeptide repeats protein / Q9P2R6* / arginine-glutamic acid dipeptide repeats*ENSMUSG0000003985243
Mta1 / Q8K4B0 / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA. / Q13330* / metastasis associated 1*ENSMUSG000000211447
Mta2 / Q9R190 / Metastasis-associated protein MTA2 / O94776* / metastasis associated 1 family member 2*ENSMUSG000000716465
Mta3 / Q924K8 / Metastasis-associated protein MTA3 / Q9BTC8* / metastasis associated 1 family member 3*ENSMUSG000000558175


Protein motifs (from Interpro)
Interpro ID Name
 IPR002951  Atrophin-like
 IPR017993  Atrophin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0009404 toxin metabolic process IDA
 biological_processGO:0009405 pathogenesis IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030011 maintenance of cell polarity IDA
 biological_processGO:0032094 response to food IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051402 neuron apoptotic process ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0090729 toxin activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

Allelic Composition: Atn1tm1.1Asp/Atn1tm1.1Asp,Rereom/Rere+
Genetic Background: involves: 129P2/OlaHsd * BTBR

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm2Rfo/Apc+,Smad4E6sad/Smad4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Apctm2Rfo/Apctm2Rfo
Genetic Background: B6.129P2-Apctm2Rfo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019803 Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*  / complex






 

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