ENSMUSG00000021144


Mus musculus

Features
Gene ID: ENSMUSG00000021144
  
Biological name :Mta1
  
Synonyms : Mta1 / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA. / Q8K4B0
  
Possible biological names infered from orthology : metastasis associated 1 / Q13330
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 113098278
Gene end: 113137206
  
Corresponding Affymetrix probe sets: 10398972 (MoGene1.0st)   1417295_at (Mouse Genome 430 2.0 Array)   1440113_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064338
Ensembl peptide - ENSMUSP00000105348
Ensembl peptide - ENSMUSP00000105349
Ensembl peptide - ENSMUSP00000009099
Ensembl peptide - ENSMUSP00000105345
NCBI entrez gene - 116870     See in Manteia.
MGI - MGI:2150037
RefSeq - XM_017314939
RefSeq - XM_006515427
RefSeq - XM_006515428
RefSeq - XM_006515429
RefSeq - XM_006515430
RefSeq - XM_006515431
RefSeq - XM_011243988
RefSeq - NM_001346696
RefSeq - NM_054081
RefSeq - XM_006515418
RefSeq - XM_006515419
RefSeq - XM_006515420
RefSeq - XM_006515421
RefSeq - XM_006515422
RefSeq - XM_006515423
RefSeq - XM_006515424
RefSeq - XM_006515425
RefSeq - XM_006515426
RefSeq Peptide - NP_001333625
RefSeq Peptide - NP_473422
swissprot - M1VHG1
swissprot - F8WHY8
swissprot - Q8K4B0
swissprot - E9PX23
Ensembl - ENSMUSG00000021144
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mta1ENSDARG00000007198Danio rerio
 MTA1ENSGALG00000002803Gallus gallus
 MTA1ENSG00000182979Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mta2 / Q9R190 / Metastasis-associated protein MTA2 / O94776* / metastasis associated 1 family member 2*ENSMUSG0000007164660
Mta3 / Q924K8 / Metastasis-associated protein MTA3 / Q9BTC8* / metastasis associated 1 family member 3*ENSMUSG0000005581760
Rere / Q80TZ9 / Arginine-glutamic acid dipeptide repeats protein / Q9P2R6* / arginine-glutamic acid dipeptide repeats*ENSMUSG0000003985223
O35126 / Gm45234 / predicted gene 45234 / ATN1* / P54259* / atrophin 1*ENSMUSG0000010747811
Atn1 / O35126 / Atrophin-1 / P54259*ENSMUSG0000000426311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR009057  Homeobox-like domain superfamily
 IPR013088  Zinc finger, NHR/GATA-type
 IPR017884  SANT domain
 IPR035170  Metastasis-associated protein MTA1, R1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1902499 positive regulation of protein autoubiquitination IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016581 NuRD complex IPI
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
SUMOylation of transcription factors
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction






 

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