ENSG00000182979


Homo sapiens

Features
Gene ID: ENSG00000182979
  
Biological name :MTA1
  
Synonyms : metastasis associated 1 / MTA1 / Q13330
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.33
Gene start: 105419820
Gene end: 105470729
  
Corresponding Affymetrix probe sets: 202247_s_at (Human Genome U133 Plus 2.0 Array)   211783_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411493
Ensembl peptide - ENSP00000394106
Ensembl peptide - ENSP00000450094
Ensembl peptide - ENSP00000333633
Ensembl peptide - ENSP00000384180
Ensembl peptide - ENSP00000385702
Ensembl peptide - ENSP00000389425
Ensembl peptide - ENSP00000393438
NCBI entrez gene - 9112     See in Manteia.
OMIM - 603526
RefSeq - XM_017021759
RefSeq - XM_011537310
RefSeq - XM_017021752
RefSeq - XM_017021753
RefSeq - XM_017021754
RefSeq - XM_017021755
RefSeq - XM_017021756
RefSeq - XM_017021757
RefSeq - XM_017021758
RefSeq - NM_001203258
RefSeq - NM_004689
RefSeq - XM_011537305
RefSeq - XM_011537306
RefSeq - XM_011537307
RefSeq - XM_011537308
RefSeq - XM_011537309
RefSeq Peptide - NP_001190187
RefSeq Peptide - NP_004680
swissprot - H0YIT0
swissprot - H7C3F3
swissprot - F8W9Y9
swissprot - E7ESY4
swissprot - Q13330
swissprot - H0Y4T7
Ensembl - ENSG00000182979
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mta1ENSDARG00000007198Danio rerio
 MTA1ENSGALG00000002803Gallus gallus
 Mta1ENSMUSG00000021144Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTA2 / O94776 / metastasis associated 1 family member 2ENSG0000014948059
MTA3 / Q9BTC8 / metastasis associated 1 family member 3ENSG0000005793558
RERE / Q9P2R6 / arginine-glutamic acid dipeptide repeatsENSG0000014259923
ATN1 / P54259 / atrophin 1ENSG0000011167611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR009057  Homeobox-like domain superfamily
 IPR013088  Zinc finger, NHR/GATA-type
 IPR017884  SANT domain
 IPR035170  Metastasis-associated protein MTA1, R1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0040029 regulation of gene expression, epigenetic IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045475 locomotor rhythm ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1902499 positive regulation of protein autoubiquitination IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IMP
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
SUMOylation of transcription factors
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction






 

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