ENSG00000057935


Homo sapiens

Features
Gene ID: ENSG00000057935
  
Biological name :MTA3
  
Synonyms : metastasis associated 1 family member 3 / MTA3 / Q9BTC8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p21
Gene start: 42494569
Gene end: 42756947
  
Corresponding Affymetrix probe sets: 223311_s_at (Human Genome U133 Plus 2.0 Array)   226852_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384249
Ensembl peptide - ENSP00000401815
Ensembl peptide - ENSP00000391455
Ensembl peptide - ENSP00000388722
Ensembl peptide - ENSP00000386763
Ensembl peptide - ENSP00000385823
Ensembl peptide - ENSP00000385241
Ensembl peptide - ENSP00000385045
Ensembl peptide - ENSP00000383973
NCBI entrez gene - 57504     See in Manteia.
OMIM - 609050
RefSeq - XM_017004562
RefSeq - NM_001282755
RefSeq - NM_001282756
RefSeq - NM_001330442
RefSeq - NM_001330443
RefSeq - NM_020744
RefSeq - XM_005264456
RefSeq - XM_005264458
RefSeq - XM_005264459
RefSeq - XM_017004561
RefSeq Peptide - NP_001269684
RefSeq Peptide - NP_001317371
RefSeq Peptide - NP_001317372
RefSeq Peptide - NP_065795
RefSeq Peptide - NP_001269685
swissprot - E9PCS8
swissprot - E9PF88
swissprot - Q9BTC8
swissprot - E7EV10
swissprot - E7EQY4
swissprot - D6W5A2
swissprot - C9JR73
Ensembl - ENSG00000057935
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mta3ENSDARG00000054903Danio rerio
 MTA3ENSGALG00000009925Gallus gallus
 Mta3ENSMUSG00000055817Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTA1 / Q13330 / metastasis associated 1ENSG0000018297970
MTA2 / O94776 / metastasis associated 1 family member 2ENSG0000014948064
RERE / Q9P2R6 / arginine-glutamic acid dipeptide repeatsENSG0000014259926
ATN1 / P54259 / atrophin 1ENSG0000011167610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR009057  Homeobox-like domain superfamily
 IPR013088  Zinc finger, NHR/GATA-type
 IPR017884  SANT domain
 IPR035170  Metastasis-associated protein MTA1, R1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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