ENSG00000149480


Homo sapiens

Features
Gene ID: ENSG00000149480
  
Biological name :MTA2
  
Synonyms : metastasis associated 1 family member 2 / MTA2 / O94776
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.3
Gene start: 62593214
Gene end: 62601840
  
Corresponding Affymetrix probe sets: 203444_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431346
Ensembl peptide - ENSP00000431797
Ensembl peptide - ENSP00000278823
NCBI entrez gene - 9219     See in Manteia.
OMIM - 603947
RefSeq - NM_004739
RefSeq - XM_017018561
RefSeq Peptide - NP_001317221
RefSeq Peptide - NP_004730
swissprot - A0A024R534
swissprot - O94776
Ensembl - ENSG00000149480
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mta2ENSDARG00000013031Danio rerio
 Mta2ENSMUSG00000071646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTA1 / Q13330 / metastasis associated 1ENSG0000018297963
MTA3 / Q9BTC8 / metastasis associated 1 family member 3ENSG0000005793557
RERE / Q9P2R6 / arginine-glutamic acid dipeptide repeatsENSG0000014259923
ATN1 / P54259 / atrophin 1ENSG0000011167610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR009057  Homeobox-like domain superfamily
 IPR013088  Zinc finger, NHR/GATA-type
 IPR017884  SANT domain
 IPR035170  Metastasis-associated protein MTA1, R1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0006333 chromatin assembly or disassembly TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010762 regulation of fibroblast migration IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling HDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000118 histone deacetylase complex TAS
 cellular_componentGO:0000790 nuclear chromatin HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016581 NuRD complex IDA
 cellular_componentGO:0032991 protein-containing complex HDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031492 nucleosomal DNA binding HDA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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