ENSMUSG00000071646


Mus musculus

Features
Gene ID: ENSMUSG00000071646
  
Biological name :Mta2
  
Synonyms : Metastasis-associated protein MTA2 / Mta2 / Q9R190
  
Possible biological names infered from orthology : metastasis associated 1 family member 2 / O94776
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 8941875
Gene end: 8952303
  
Corresponding Affymetrix probe sets: 10461334 (MoGene1.0st)   1423165_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093959
NCBI entrez gene - 23942     See in Manteia.
MGI - MGI:1346340
RefSeq - XM_017318190
RefSeq - NM_011842
RefSeq - XM_017318189
RefSeq Peptide - NP_035972
swissprot - Q9R190
Ensembl - ENSMUSG00000071646
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mta2ENSDARG00000013031Danio rerio
 MTA2ENSG00000149480Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mta1 / Q8K4B0 / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA. / Q13330* / metastasis associated 1*ENSMUSG0000002114463
Mta3 / Q924K8 / Metastasis-associated protein MTA3 / Q9BTC8* / metastasis associated 1 family member 3*ENSMUSG0000005581757
Rere / Q80TZ9 / Arginine-glutamic acid dipeptide repeats protein / Q9P2R6* / arginine-glutamic acid dipeptide repeats*ENSMUSG0000003985222
Atn1 / O35126 / Atrophin-1 / P54259*ENSMUSG0000000426310
O35126 / Gm45234 / predicted gene 45234 / ATN1* / P54259* / atrophin 1*ENSMUSG0000010747810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR009057  Homeobox-like domain superfamily
 IPR013088  Zinc finger, NHR/GATA-type
 IPR017884  SANT domain
 IPR035170  Metastasis-associated protein MTA1, R1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006306 DNA methylation IMP
 biological_processGO:0006323 DNA packaging TAS
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010762 regulation of fibroblast migration IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0016581 NuRD complex ISO
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004407 histone deacetylase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hydinhyrh/Hydinhyrh
Genetic Background: involves: C57BL/6J * C57BL/10J * RIII

Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011164 panniculitis "inflammation of the subcutaneous adipose tissue" [ISBN:0-683-40008-8]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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