ENSMUSG00000039852


Mus musculus

Features
Gene ID: ENSMUSG00000039852
  
Biological name :Rere
  
Synonyms : Arginine-glutamic acid dipeptide repeats protein / Q80TZ9 / Rere
  
Possible biological names infered from orthology : arginine-glutamic acid dipeptide repeats / Q9P2R6
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 150281646
Gene end: 150621966
  
Corresponding Affymetrix probe sets: 10510552 (MoGene1.0st)   1439159_at (Mouse Genome 430 2.0 Array)   1454670_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151591
Ensembl peptide - ENSMUSP00000101305
Ensembl peptide - ENSMUSP00000101307
Ensembl peptide - ENSMUSP00000115385
Ensembl peptide - ENSMUSP00000121544
NCBI entrez gene - 68703     See in Manteia.
MGI - MGI:2683486
RefSeq - XM_006539147
RefSeq - XM_006539140
RefSeq - XM_006539141
RefSeq - XM_006539142
RefSeq - XM_006539143
RefSeq - XM_006539144
RefSeq - XM_006539145
RefSeq - NM_001085492
RefSeq - XM_006539136
RefSeq - XM_006539137
RefSeq - XM_006539138
RefSeq - XM_006539139
RefSeq Peptide - NP_001078961
swissprot - B1AS11
swissprot - A2A7T3
swissprot - A2A7T1
swissprot - A0A1W2P787
swissprot - Q80TZ9
Ensembl - ENSMUSG00000039852
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rereaENSDARG00000077353Danio rerio
 rerebENSDARG00000075670Danio rerio
 REREENSGALG00000002232Gallus gallus
 REREENSG00000142599Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atn1 / O35126 / Atrophin-1 / P54259*ENSMUSG0000000426332
O35126 / Gm45234 / predicted gene 45234 / ATN1* / P54259* / atrophin 1*ENSMUSG0000010747832
Mta3 / Q924K8 / Metastasis-associated protein MTA3 / Q9BTC8* / metastasis associated 1 family member 3*ENSMUSG0000005581710
Mta1 / Q8K4B0 / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA. / Q13330* / metastasis associated 1*ENSMUSG0000002114410
Mta2 / Q9R190 / Metastasis-associated protein MTA2 / O94776* / metastasis associated 1 family member 2*ENSMUSG000000716469


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR002951  Atrophin-like
 IPR009057  Homeobox-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR013088  Zinc finger, NHR/GATA-type
 IPR017884  SANT domain
 IPR017993  Atrophin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006338 chromatin remodeling IPI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021691 cerebellar Purkinje cell layer maturation IMP
 biological_processGO:0021930 cerebellar granule cell precursor proliferation IMP
 biological_processGO:0021942 radial glia guided migration of Purkinje cell IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048755 branching morphogenesis of a nerve IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0000118 histone deacetylase complex IPI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atn1tm1.1Asp/Atn1tm1.1Asp,Rereom/Rere+
Genetic Background: involves: 129P2/OlaHsd * BTBR

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0003604 single kidney 
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0005222 abnormal somite size "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0009939 abnormal hippocampus neuron morphology 
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0010487 abnormal right subclavian artery morphology "any structural anomaly of the artery that normally extends from the brachiocephalic artery to the right side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0010488 abnormal left subclavian artery morphology "any structural anomaly of the artery that extends from the aortic arch to the left side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: B6.Cg-Rereeyes3/Rereom

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Rereeyes3/Rereom
Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

 MP:0030191 narrow snout "decreased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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