ENSMUSG00000055817


Mus musculus

Features
Gene ID: ENSMUSG00000055817
  
Biological name :Mta3
  
Synonyms : Metastasis-associated protein MTA3 / Mta3 / Q924K8
  
Possible biological names infered from orthology : metastasis associated 1 family member 3 / Q9BTC8
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 83706163
Gene end: 83821516
  
Corresponding Affymetrix probe sets: 10447167 (MoGene1.0st)   1421402_at (Mouse Genome 430 2.0 Array)   1451352_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135752
Ensembl peptide - ENSMUSP00000134775
Ensembl peptide - ENSMUSP00000135064
Ensembl peptide - ENSMUSP00000068931
Ensembl peptide - ENSMUSP00000107968
Ensembl peptide - ENSMUSP00000107969
Ensembl peptide - ENSMUSP00000107971
NCBI entrez gene - 116871     See in Manteia.
MGI - MGI:2151172
RefSeq - XM_017317214
RefSeq - NM_001171052
RefSeq - NM_001171053
RefSeq - NM_001171054
RefSeq - NM_054082
RefSeq - XM_006523506
RefSeq - XM_006523507
RefSeq - XM_006523508
RefSeq - XM_006523509
RefSeq - XM_006523510
RefSeq - XM_006523511
RefSeq - XM_017317213
RefSeq Peptide - NP_001164523
RefSeq Peptide - NP_001164524
RefSeq Peptide - NP_001164525
RefSeq Peptide - NP_473423
swissprot - Q3UII8
swissprot - H3BJP3
swissprot - E9Q794
swissprot - Q924K8
swissprot - H3BLE1
swissprot - H3BIY7
swissprot - Q3U3A7
Ensembl - ENSMUSG00000055817
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mta3ENSDARG00000054903Danio rerio
 MTA3ENSGALG00000009925Gallus gallus
 MTA3ENSG00000057935Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mta1 / Q8K4B0 / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA. / Q13330* / metastasis associated 1*ENSMUSG0000002114471
Mta2 / Q9R190 / Metastasis-associated protein MTA2 / O94776* / metastasis associated 1 family member 2*ENSMUSG0000007164664
Rere / Q80TZ9 / Arginine-glutamic acid dipeptide repeats protein / Q9P2R6* / arginine-glutamic acid dipeptide repeats*ENSMUSG0000003985226
Atn1 / O35126 / Atrophin-1 / P54259*ENSMUSG0000000426310
O35126 / Gm45234 / predicted gene 45234 / ATN1* / P54259* / atrophin 1*ENSMUSG0000010747810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR009057  Homeobox-like domain superfamily
 IPR013088  Zinc finger, NHR/GATA-type
 IPR017884  SANT domain
 IPR035170  Metastasis-associated protein MTA1, R1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0003062 abnormal coping response "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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