ENSG00000163586


Homo sapiens

Features
Gene ID: ENSG00000163586
  
Biological name :FABP1
  
Synonyms : FABP1 / fatty acid binding protein 1 / P07148
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p11.2
Gene start: 88122982
Gene end: 88128116
  
Corresponding Affymetrix probe sets: 205892_s_at (Human Genome U133 Plus 2.0 Array)   231693_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295834
Ensembl peptide - ENSP00000377351
NCBI entrez gene - 2168     See in Manteia.
OMIM - 134650
RefSeq - NM_001443
RefSeq Peptide - NP_001434
swissprot - A8MW49
swissprot - P07148
swissprot - Q6FGL7
Ensembl - ENSG00000163586
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fabp1aENSDARG00000019357Danio rerio
 fabp1b.2ENSDARG00000103398Danio rerio
 Q4VBT1ENSDARG00000059227Danio rerio
 FABP1ENSGALG00000015937Gallus gallus
 Fabp1ENSMUSG00000054422Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FABP6 / P51161 / fatty acid binding protein 6ENSG0000017023137


Protein motifs (from Interpro)
Interpro ID Name
 IPR000463  Cytosolic fatty-acid binding
 IPR012674  Calycin
 IPR031259  Intracellular lipid binding protein
 IPR031276  Liver basic fatty acid-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015909 long-chain fatty acid transport IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019433 triglyceride catabolic process TAS
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0050892 intestinal absorption IEA
 biological_processGO:0051345 positive regulation of hydrolase activity IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005782 peroxisomal matrix IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0045179 apical cortex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005324 long-chain fatty acid transporter activity IEA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016209 antioxidant activity IDA
 molecular_functionGO:0032052 bile acid binding IEA


Pathways (from Reactome)
Pathway description
Triglyceride catabolism
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / reaction
 ENSG00000186951 PPARA / Q07869 / peroxisome proliferator activated receptor alpha  / reaction
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / reaction






 

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