ENSG00000100429


Homo sapiens

Features
Gene ID: ENSG00000100429
  
Biological name :HDAC10
  
Synonyms : HDAC10 / histone deacetylase 10 / Q969S8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.33
Gene start: 50245183
Gene end: 50251405
  
Corresponding Affymetrix probe sets: 226672_s_at (Human Genome U133 Plus 2.0 Array)   232870_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406150
Ensembl peptide - ENSP00000407640
Ensembl peptide - ENSP00000486864
Ensembl peptide - ENSP00000216271
Ensembl peptide - ENSP00000343540
Ensembl peptide - ENSP00000397517
Ensembl peptide - ENSP00000397542
NCBI entrez gene - 83933     See in Manteia.
OMIM - 608544
RefSeq - NM_032019
RefSeq - NM_001159286
RefSeq Peptide - NP_001152758
RefSeq Peptide - NP_114408
swissprot - Q969S8
swissprot - Q08AP5
swissprot - C9J8B8
Ensembl - ENSG00000100429
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac10ENSDARG00000086458Danio rerio
 HDAC10ENSGALG00000041251Gallus gallus
 Hdac10ENSMUSG00000062906Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HDAC6 / Q9UBN7 / histone deacetylase 6ENSG0000009463141
HDAC4 / P56524 / histone deacetylase 4ENSG0000006802419
HDAC9 / Q9UKV0 / histone deacetylase 9ENSG0000004805218
HDAC5 / Q9UQL6 / histone deacetylase 5ENSG0000010884018
HDAC7 / Q8WUI4 / histone deacetylase 7ENSG0000006127316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006325 chromatin organization NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IDA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0016575 histone deacetylation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0070932 histone H3 deacetylation IEA
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IDA
 molecular_functionGO:0042826 histone deacetylase binding IDA


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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