ENSMUSG00000022475


Mus musculus

Features
Gene ID: ENSMUSG00000022475
  
Biological name :Hdac7
  
Synonyms : Hdac7 / Histone deacetylase 7 / Q8C2B3
  
Possible biological names infered from orthology : Q8WUI4
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 97792664
Gene end: 97844502
  
Corresponding Affymetrix probe sets: 10432006 (MoGene1.0st)   1420812_at (Mouse Genome 430 2.0 Array)   1420813_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113380
Ensembl peptide - ENSMUSP00000112641
Ensembl peptide - ENSMUSP00000118599
Ensembl peptide - ENSMUSP00000120576
Ensembl peptide - ENSMUSP00000119970
Ensembl peptide - ENSMUSP00000078766
Ensembl peptide - ENSMUSP00000085744
Ensembl peptide - ENSMUSP00000112109
Ensembl peptide - ENSMUSP00000112110
Ensembl peptide - ENSMUSP00000112446
Ensembl peptide - ENSMUSP00000112459
NCBI entrez gene - 56233     See in Manteia.
MGI - MGI:1891835
RefSeq - XM_011245699
RefSeq - NM_001204275
RefSeq - NM_001204276
RefSeq - NM_001204277
RefSeq - NM_001204278
RefSeq - NM_001204279
RefSeq - NM_001204280
RefSeq - NM_001204281
RefSeq - NM_019572
RefSeq - XM_006521203
RefSeq - XM_006521205
RefSeq - XM_006521207
RefSeq - XM_006521208
RefSeq - XM_006521209
RefSeq - XM_006521210
RefSeq Peptide - NP_001191204
RefSeq Peptide - NP_001191206
RefSeq Peptide - NP_001191207
RefSeq Peptide - NP_001191208
RefSeq Peptide - NP_001191209
RefSeq Peptide - NP_001191210
RefSeq Peptide - NP_062518
RefSeq Peptide - NP_001191205
swissprot - E9PZG4
swissprot - E9PXW8
swissprot - F6RY11
swissprot - F6VIB5
swissprot - E9PXW1
swissprot - Q8C2B3
swissprot - E9PX62
Ensembl - ENSMUSG00000022475
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01074076.1ENSDARG00000105179Danio rerio
 hdac7bENSDARG00000073850Danio rerio
 HDAC7ENSGALG00000039710Gallus gallus
 HDAC7ENSG00000061273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*ENSMUSG0000002631350
Hdac5 / histone deacetylase 5 isoform 4 / Q9UQL6* / histone deacetylase 5*ENSMUSG0000000885544
Hdac6 / Q9Z2V5 / Histone deacetylase 6 / Q9UBN7*ENSMUSG0000003116124
Hdac9 / histone deacetylase 9 / Q9UKV0*ENSMUSG0000000469814
Hdac10 / Q6P3E7 / Histone deacetylase 10 / Q969S8*ENSMUSG0000006290610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR017320  Histone deacetylase class II, eukaryotic
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007043 cell-cell junction assembly IMP
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0030183 B cell differentiation TAS
 biological_processGO:0032703 negative regulation of interleukin-2 production ISO
 biological_processGO:0042113 B cell activation TAS
 biological_processGO:0045668 negative regulation of osteoblast differentiation ISO
 biological_processGO:0045843 negative regulation of striated muscle tissue development TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated TAS
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISO
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling ISO
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005080 protein kinase C binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding ISO
 molecular_functionGO:0071889 14-3-3 protein binding ISS


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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