ENSMUSG00000004698


Mus musculus

Features
Gene ID: ENSMUSG00000004698
  
Biological name :Hdac9
  
Synonyms : Hdac9 / histone deacetylase 9
  
Possible biological names infered from orthology : Q9UKV0
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A3
Gene start: 34047580
Gene end: 34917095
  
Corresponding Affymetrix probe sets: 10399973 (MoGene1.0st)   1421306_a_at (Mouse Genome 430 2.0 Array)   1434572_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106443
Ensembl peptide - ENSMUSP00000147519
Ensembl peptide - ENSMUSP00000147395
Ensembl peptide - ENSMUSP00000148224
Ensembl peptide - ENSMUSP00000148029
Ensembl peptide - ENSMUSP00000148007
Ensembl peptide - ENSMUSP00000147903
Ensembl peptide - ENSMUSP00000147869
Ensembl peptide - ENSMUSP00000147755
NCBI entrez gene - 79221     See in Manteia.
MGI - MGI:1931221
RefSeq - XM_017315253
RefSeq - XM_011243913
RefSeq - XM_011243916
RefSeq - XM_011243917
RefSeq - XM_011243918
RefSeq - XM_011243921
RefSeq - XM_011243922
RefSeq - XM_017315248
RefSeq - XM_017315249
RefSeq - XM_017315250
RefSeq - XM_017315251
RefSeq - XM_017315252
RefSeq - NM_001271386
RefSeq - NM_024124
RefSeq - XM_006515261
RefSeq - XM_006515262
RefSeq - XM_006515264
RefSeq - XM_006515266
RefSeq - XM_006515271
RefSeq - XM_006515273
RefSeq - XM_006515275
RefSeq - XM_006515276
RefSeq - XM_011243911
RefSeq - XM_011243912
RefSeq Peptide - NP_077038
RefSeq Peptide - NP_001258315
swissprot - A0A1B0GSN4
swissprot - A0A1B0GSE4
swissprot - A0A1B0GSB5
swissprot - A0A1B0GT67
swissprot - A0A1B0GRH0
swissprot - A0A1B0GR65
swissprot - A0A0R4J1F3
swissprot - A0A1B0GS15
swissprot - A0A1B0GSQ5
Ensembl - ENSMUSG00000004698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac9bENSDARG00000056642Danio rerio
 HDAC9ENSGALG00000010854Gallus gallus
 HDAC9ENSG00000048052Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac5 / histone deacetylase 5 isoform 4 / Q9UQL6* / histone deacetylase 5*ENSMUSG0000000885551
Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*ENSMUSG0000002631349
Hdac7 / Q8C2B3 / Histone deacetylase 7 / Q8WUI4*ENSMUSG0000002247523
Hdac6 / Q9Z2V5 / Histone deacetylase 6 / Q9UBN7*ENSMUSG0000003116113
Hdac10 / Q6P3E7 / Histone deacetylase 10 / Q969S8*ENSMUSG0000006290610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017320  Histone deacetylase class II, eukaryotic
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR024643  Histone deacetylase, glutamine rich N-terminal domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0070933 histone H4 deacetylation IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hdac9tm1Eno/Hdac9tm1Eno,Tg(Myh6-Ppp3ca)37Eno/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx2tm1Rsd/Pitx2tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Hdac4tm1Eno/Hdac4+,Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9+
Genetic Background: involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Hdac9tm1Eno/Hdac9tm1Eno
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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