ENSG00000101412


Homo sapiens

Features
Gene ID: ENSG00000101412
  
Biological name :E2F1
  
Synonyms : E2F1 / E2F transcription factor 1 / Q01094
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.22
Gene start: 33675683
Gene end: 33686404
  
Corresponding Affymetrix probe sets: 2028_s_at (Human Genome U133 Plus 2.0 Array)   204947_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345571
NCBI entrez gene - 1869     See in Manteia.
OMIM - 189971
RefSeq - NM_005225
RefSeq Peptide - NP_005216
swissprot - Q01094
Ensembl - ENSG00000101412
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f1ENSDARG00000103868Danio rerio
 E2F1ENSGALG00000003045Gallus gallus
 E2f1ENSMUSG00000027490Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F3 / O00716 / E2F transcription factor 3ENSG0000011224241
E2F2 / Q14209 / E2F transcription factor 2ENSG0000000796840
E2F4 / Q16254 / E2F transcription factor 4ENSG0000020525026
E2F5 / Q15329 / E2F transcription factor 5ENSG0000013374025
E2F6 / O75461 / E2F transcription factor 6ENSG0000016901623


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043276 anoikis IEA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048255 mRNA stabilization IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:0070345 negative regulation of fat cell proliferation IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071466 cellular response to xenobiotic stimulus IEA
 biological_processGO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1990086 lens fiber cell apoptotic process IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035189 Rb-E2F complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Activation of E2F1 target genes at G1/S
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / complex / reaction
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / reaction / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex






 

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