ENSG00000204086


Homo sapiens

Features
Gene ID: ENSG00000204086
  
Biological name :RPA4
  
Synonyms : Q13156 / replication protein A4 / RPA4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q21.33
Gene start: 96883908
Gene end: 96885467
  
Corresponding Affymetrix probe sets: 221143_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362131
NCBI entrez gene - 29935     See in Manteia.
OMIM - 300767
RefSeq - NM_013347
RefSeq Peptide - NP_037479
swissprot - Q13156
Ensembl - ENSG00000204086
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpa2ENSDARG00000037188Danio rerio
 RPA2ENSGALG00000000734Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RPA2 / P15927 / replication protein A2ENSG0000011774843


Protein motifs (from Interpro)
Interpro ID Name
 IPR012340  Nucleic acid-binding, OB-fold
 IPR014646  Replication factor A protein 2
 IPR014892  Replication protein A, C-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IDA
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IDA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005662 DNA replication factor A complex TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding TAS


Pathways (from Reactome)
Pathway description
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / complex / reaction
 ENSG00000097046 CDC7 / O00311 / cell division cycle 7  / complex / reaction
 ENSG00000006634 DBF4 / Q9UBU7 / DBF4 zinc finger  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000093009 CDC45 / O75419 / cell division cycle 45  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex
 ENSG00000065328 MCM10 / Q7L590 / minichromosome maintenance 10 replication initiation factor  / complex / reaction






 

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