ENSMUSG00000028587


Mus musculus

Features
Gene ID: ENSMUSG00000028587
  
Biological name :Orc1
  
Synonyms : Orc1 / Origin recognition complex subunit 1 / Q9Z1N2
  
Possible biological names infered from orthology : Q13415
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 108579423
Gene end: 108614833
  
Corresponding Affymetrix probe sets: 10506822 (MoGene1.0st)   1422663_at (Mouse Genome 430 2.0 Array)   1443172_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099805
NCBI entrez gene - 18392     See in Manteia.
MGI - MGI:1328337
RefSeq - NM_011015
RefSeq - XM_011240469
RefSeq Peptide - NP_035145
swissprot - Q9Z1N2
Ensembl - ENSMUSG00000028587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 orc1ENSDARG00000039217Danio rerio
 ORC1ENSGALG00000010623Gallus gallus
 ORC1ENSG00000085840Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*ENSMUSG0000001749916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR015163  Cdc6, C-terminal
 IPR020793  Origin recognition complex, subunit 1
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication TAS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000808 origin recognition complex IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005664 nuclear origin of replication recognition complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Orc1tm1a(KOMP)Wtsi/Orc1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Orc1tm1a(KOMP)Wtsi/Wtsi

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Orc1tm1a(KOMP)Wtsi/Orc1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Orc1tm1a(KOMP)Wtsi/Wtsi

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Orc1tm1a(KOMP)Wtsi/Orc1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Orc1tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026761 Orc4 / O88708 / Mus musculus origin recognition complex, subunit 4 (Orc4), transcript variant 4, mRNA. / O43929* / origin recognition complex subunit 4*  / complex / reaction
 ENSMUSG00000026037 Orc2 / Q60862 / Origin recognition complex subunit 2 / Q13416*  / complex / reaction
 ENSMUSG00000029012 Orc5 / Q9WUV0 / Origin recognition complex subunit 5 / O43913*  / complex / reaction
 ENSMUSG00000040044 Orc3 / Q9JK30 / Origin recognition complex subunit 3 / Q9UBD5*  / reaction / complex






 

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