ENSMUSG00000026761


Mus musculus

Features
Gene ID: ENSMUSG00000026761
  
Biological name :Orc4
  
Synonyms : Mus musculus origin recognition complex, subunit 4 (Orc4), transcript variant 4, mRNA. / O88708 / Orc4
  
Possible biological names infered from orthology : O43929 / origin recognition complex subunit 4
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.1
Gene start: 48902824
Gene end: 48950277
  
Corresponding Affymetrix probe sets: 10482467 (MoGene1.0st)   1423336_at (Mouse Genome 430 2.0 Array)   1423337_at (Mouse Genome 430 2.0 Array)   1431172_at (Mouse Genome 430 2.0 Array)   1453804_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121114
Ensembl peptide - ENSMUSP00000088497
Ensembl peptide - ENSMUSP00000117732
Ensembl peptide - ENSMUSP00000119274
Ensembl peptide - ENSMUSP00000028098
NCBI entrez gene - 26428     See in Manteia.
MGI - MGI:1347043
RefSeq - XM_006498066
RefSeq - NM_001177313
RefSeq - NM_001355296
RefSeq - NM_011958
RefSeq - XM_006498063
RefSeq - XM_006498064
RefSeq - XM_006498065
RefSeq Peptide - NP_001342225
RefSeq Peptide - NP_036088
RefSeq Peptide - NP_001170784
swissprot - A2AI42
swissprot - O88708
swissprot - Q9CZF7
swissprot - A2AI40
swissprot - A2AI43
Ensembl - ENSMUSG00000026761
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 orc4ENSDARG00000101161Danio rerio
 ORC4ENSGALG00000012448Gallus gallus
 ORC4ENSG00000115947Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001482  Type II/IV secretion system protein
 IPR003593  AAA+ ATPase domain
 IPR016527  Origin recognition complex subunit 4
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032705  Origin recognition complex subunit 4, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006270 DNA replication initiation IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000808 origin recognition complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005664 nuclear origin of replication recognition complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029012 Orc5 / Q9WUV0 / Origin recognition complex subunit 5 / O43913*  / reaction / complex
 ENSMUSG00000028587 Orc1 / Q9Z1N2 / Origin recognition complex subunit 1 / Q13415*  / reaction / complex
 ENSMUSG00000040044 Orc3 / Q9JK30 / Origin recognition complex subunit 3 / Q9UBD5*  / reaction / complex
 ENSMUSG00000026037 Orc2 / Q60862 / Origin recognition complex subunit 2 / Q13416*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr