ENSDARG00000101161


Danio rerio

Features
Gene ID: ENSDARG00000101161
  
Biological name :orc4
  
Synonyms : orc4 / origin recognition complex, subunit 4
  
Possible biological names infered from orthology : Mus musculus origin recognition complex, subunit 4 (Orc4), transcript variant 4, mRNA. / O43929 / O88708
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 1748463
Gene end: 1762191
  
Corresponding Affymetrix probe sets: Dr.20190.1.S1_at (Zebrafish Array)   Dr.25348.1.A1_x_at (Zebrafish Array)   NM_213183_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000130427
Ensembl peptide - ENSDARP00000141716
NCBI entrez gene - 406462     See in Manteia.
RefSeq - NM_213183
RefSeq - XM_005168697
RefSeq Peptide - NP_998348
swissprot - F1QRE0
ZFIN ID - ZDB-GENE-040426-2224
Ensembl - ENSDARG00000101161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ORC4ENSGALG00000012448Gallus gallus
 ORC4ENSG00000115947Homo sapiens
 Orc4ENSMUSG00000026761Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR016527  Origin recognition complex subunit 4
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032705  Origin recognition complex subunit 4, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IBA
 cellular_componentGO:0000808 origin recognition complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005664 nuclear origin of replication recognition complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IBA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008805 orc3 / origin recognition complex, subunit 3 / Q9JK30* / Q9UBD5*  / complex / reaction
 ENSDARG00000039217 orc1 / origin recognition complex, subunit 1 / Q13415* / Q9Z1N2*  / complex / reaction
 ENSDARG00000075682 orc6 / origin recognition complex, subunit 6 / Q9Y5N6*  / reaction
 ENSDARG00000021579 orc5 / origin recognition complex, subunit 5 / O43913* / Q9WUV0*  / complex / reaction






 

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