ENSMUSG00000040044


Mus musculus

Features
Gene ID: ENSMUSG00000040044
  
Biological name :Orc3
  
Synonyms : Orc3 / Origin recognition complex subunit 3 / Q9JK30
  
Possible biological names infered from orthology : Q9UBD5
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 34570796
Gene end: 34614944
  
Corresponding Affymetrix probe sets: 10511952 (MoGene1.0st)   1416115_at (Mouse Genome 430 2.0 Array)   1416116_at (Mouse Genome 430 2.0 Array)   1416117_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048319
Ensembl peptide - ENSMUSP00000103777
Ensembl peptide - ENSMUSP00000119335
NCBI entrez gene - 50793     See in Manteia.
MGI - MGI:1354944
RefSeq - XM_017320309
RefSeq - NM_001159563
RefSeq - NM_015824
RefSeq - XM_011250066
RefSeq Peptide - NP_056639
RefSeq Peptide - NP_001153035
swissprot - Q9JK30
swissprot - A2AT40
Ensembl - ENSMUSG00000040044
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 orc3ENSDARG00000008805Danio rerio
 ORC3ENSGALG00000015800Gallus gallus
 ORC3ENSG00000135336Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR020795  Origin recognition complex, subunit 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0014009 glial cell proliferation IC
 biological_processGO:0061351 neural precursor cell proliferation IMP
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IBA
 cellular_componentGO:0000808 origin recognition complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005656 nuclear pre-replicative complex IBA
 cellular_componentGO:0005664 nuclear origin of replication recognition complex IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031261 DNA replication preinitiation complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IBA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Orc1tm1a(KOMP)Wtsi/Orc1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Orc1tm1a(KOMP)Wtsi/Wtsi

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0020388 decreased radial glial cell number "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25698753]
Show

Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
Show

Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026761 Orc4 / O88708 / Mus musculus origin recognition complex, subunit 4 (Orc4), transcript variant 4, mRNA. / O43929* / origin recognition complex subunit 4*  / reaction / complex
 ENSMUSG00000029012 Orc5 / Q9WUV0 / Origin recognition complex subunit 5 / O43913*  / reaction / complex
 ENSMUSG00000028587 Orc1 / Q9Z1N2 / Origin recognition complex subunit 1 / Q13415*  / complex / reaction
 ENSMUSG00000026037 Orc2 / Q60862 / Origin recognition complex subunit 2 / Q13416*  / reaction / complex






 

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