ENSG00000105173


Homo sapiens

Features
Gene ID: ENSG00000105173
  
Biological name :CCNE1
  
Synonyms : CCNE1 / cyclin E1 / P24864
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q12
Gene start: 29811898
Gene end: 29824308
  
Corresponding Affymetrix probe sets: 213523_at (Human Genome U133 Plus 2.0 Array)   242105_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262643
Ensembl peptide - ENSP00000410179
Ensembl peptide - ENSP00000459024
Ensembl peptide - ENSP00000460881
Ensembl peptide - ENSP00000350625
NCBI entrez gene - 898     See in Manteia.
OMIM - 123837
RefSeq - XM_011527440
RefSeq - NM_001238
RefSeq - NM_001322259
RefSeq - NM_001322261
RefSeq - NM_001322262
RefSeq Peptide - NP_001229
RefSeq Peptide - NP_001309188
RefSeq Peptide - NP_001309190
RefSeq Peptide - NP_001309191
swissprot - I3L1Q9
swissprot - C9J2U0
swissprot - P24864
swissprot - I3L413
Ensembl - ENSG00000105173
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccne1ENSDARG00000098622Danio rerio
 CCNE1ENSGALG00000004494Gallus gallus
 Ccne1ENSMUSG00000002068Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNE2 / O96020 / cyclin E2ENSG0000017530548
CCNB1 / P14635 / cyclin B1ENSG0000013405721
CCNA1 / P78396 / cyclin A1ENSG0000013310119
CCNA2 / P20248 / cyclin A2ENSG0000014538619
CCNB2 / O95067 / cyclin B2ENSG0000015745618
CCNB3 / Q8WWL7 / cyclin B3ENSG0000014708218
CCND3 / P30281 / cyclin D3ENSG0000011257617
CCND1 / P24385 / cyclin D1ENSG0000011009217
CCND2 / P30279 / cyclin D2ENSG0000011897116
CCNO / P22674 / cyclin OENSG0000015266914


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028858  Cyclin E
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0097134 cyclin E1-CDK2 complex IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0050681 androgen receptor binding NAS


Pathways (from Reactome)
Pathway description
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Association of TriC/CCT with target proteins during biosynthesis
Activation of E2F1 target genes at G1/S
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
p53-Dependent G1 DNA Damage Response
PTK6 Regulates Cell Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / complex
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / reaction / complex
 ENSG00000173207 CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B  / complex / reaction
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / reaction / complex
 ENSG00000164045 CDC25A / P30304 / cell division cycle 25A  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr