ENSG00000166483


Homo sapiens

Features
Gene ID: ENSG00000166483
  
Biological name :WEE1
  
Synonyms : P30291 / WEE1 / WEE1 G2 checkpoint kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 9573681
Gene end: 9593457
  
Corresponding Affymetrix probe sets: 212533_at (Human Genome U133 Plus 2.0 Array)   215711_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434446
Ensembl peptide - ENSP00000402084
Ensembl peptide - ENSP00000435945
Ensembl peptide - ENSP00000432284
Ensembl peptide - ENSP00000434148
Ensembl peptide - ENSP00000299613
NCBI entrez gene - 7465     See in Manteia.
OMIM - 193525
RefSeq - NM_003390
RefSeq - NM_001143976
RefSeq Peptide - NP_001137448
RefSeq Peptide - NP_003381
swissprot - E9PRU3
swissprot - P30291
swissprot - E9PRI3
swissprot - E9PQ51
swissprot - H0YEJ2
Ensembl - ENSG00000166483
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wee1ENSDARG00000093864Danio rerio
 WEE1ENSGALG00000005769Gallus gallus
 Wee1ENSMUSG00000031016Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WEE2 / P0C1S8 / WEE1 homolog 2ENSG0000021410240
PKMYT1 / Q99640 / protein kinase, membrane associated tyrosine/threonine 1ENSG0000012756420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017164  Wee1-like protein kinase
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134508 Q8TDN4 / CABLES1 / Cdk5 and Abl enzyme substrate 1  / reaction / complex
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000149554 CHEK1 / O14757 / checkpoint kinase 1  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr