ENSDARG00000093864


Danio rerio

Features
Gene ID: ENSDARG00000093864
  
Biological name :wee1
  
Synonyms : wee1 / WEE1 G2 checkpoint kinase
  
Possible biological names infered from orthology : P30291 / P47810 / WEE 1 homolog 1 (S. pombe)
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 16918426
Gene end: 16924221
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000105540
Ensembl peptide - ENSDARP00000148762
NCBI entrez gene - 327060     See in Manteia.
swissprot - Q1LYE1
ZFIN ID - ZDB-GENE-030131-5268
Ensembl - ENSDARG00000093864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WEE1ENSGALG00000005769Gallus gallus
 WEE1ENSG00000166483Homo sapiens
 Wee1ENSMUSG00000031016Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wee2 / Q1LX51 / WEE1 homolog 2 (S. pombe) / Q66JT0* / P0C1S8* / WEE1 homolog 2*ENSDARG0000001271841
pkmyt1 / protein kinase, membrane associated tyrosine/threonine 1 / Q99640* / Q9ESG9* / Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase *ENSDARG0000007473019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017164  Wee1-like protein kinase
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0009416 response to light stimulus IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism structure , abnormal
whole organism viability , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000058471 plk1 / polo-like kinase 1 (Drosophila) / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / reaction
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction






 

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