ENSG00000137807


Homo sapiens

Features
Gene ID: ENSG00000137807
  
Biological name :KIF23
  
Synonyms : KIF23 / kinesin family member 23 / Q02241
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q23
Gene start: 69414246
Gene end: 69448427
  
Corresponding Affymetrix probe sets: 204709_s_at (Human Genome U133 Plus 2.0 Array)   244427_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494167
Ensembl peptide - ENSP00000453576
Ensembl peptide - ENSP00000453629
Ensembl peptide - ENSP00000260363
Ensembl peptide - ENSP00000304978
Ensembl peptide - ENSP00000378790
Ensembl peptide - ENSP00000453386
NCBI entrez gene - 9493     See in Manteia.
OMIM - 605064
RefSeq - XM_017022733
RefSeq - NM_138555
RefSeq - XM_005254796
RefSeq - XM_005254797
RefSeq - XM_005254798
RefSeq - XM_005254799
RefSeq - XM_011522238
RefSeq - XM_011522239
RefSeq - NM_001281301
RefSeq - NM_004856
RefSeq Peptide - NP_612565
RefSeq Peptide - NP_001268230
RefSeq Peptide - NP_004847
swissprot - H0YME6
swissprot - Q02241
swissprot - H7BYN4
swissprot - H0YMJ4
Ensembl - ENSG00000137807
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif23ENSDARG00000014943Danio rerio
 KIF23ENSGALG00000008095Gallus gallus
 Kif23ENSMUSG00000032254Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIF20B / Q96Q89 / kinesin family member 20BENSG0000013818222
KIF18A / Q8NI77 / kinesin family member 18AENSG0000012162118
KIF24 / Q5T7B8 / kinesin family member 24ENSG0000018663818
KIF20A / O95235 / kinesin family member 20AENSG0000011298418
KIF19 / Q2TAC6 / kinesin family member 19ENSG0000019616917
KIF18B / Q86Y91 / kinesin family member 18BENSG0000018618516
KIF22 / Q14807 / kinesin family member 22ENSG0000007961615
KIF2C / Q99661 / kinesin family member 2CENSG0000014294514
KIF2A / O00139 / kinesin family member 2AENSG0000006879614
KIF2B / Q8N4N8 / kinesin family member 2BENSG0000014120013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR032384  Kinesin-like protein Kif23, Arf6-interacting domain
 IPR032924  Kinesin-like protein KIF23
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000022 mitotic spindle elongation TAS
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0000910 cytokinesis IEA
 biological_processGO:0000915 actomyosin contractile ring assembly IEA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0051256 mitotic spindle midzone assembly IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0072383 plus-end-directed vesicle transport along microtubule IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0072686 mitotic spindle IDA
 cellular_componentGO:0090543 Flemming body IEA
 cellular_componentGO:0097149 centralspindlin complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0016887 ATPase activity IBA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Telophase/Cytokinesis
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000225 Gingival bleeding 
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 HP:0000980 Pallor 
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 HP:0001903 Anemia 
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 HP:0002249 Melena 
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 HP:0002315 Headache "Cephalgia, or pain in the head originating from the cerebral vault." [HPO:curators]
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 HP:0002904 Hyperbilirubinemia 
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 HP:0002910 Elevated transaminases "Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage." [HPO:curators]
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 HP:0003452 Increased serum iron 
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 HP:0004322 Decreased body height "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators]
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 HP:0004447 Poikilocytosis 
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 HP:0005518 Erythrocyte macrocytosis 
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 HP:0011273 Anisocytosis "Abnormally increased variability in the size of erythrocytes." [HPO:probinson]
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 HP:0011891 Post-partum hemorrhage "Significant maternal haemorrhage/blood loss following deilvery of a child." [DDD:akelly]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0025035 Abnormal proerythroblast morphology "Anomalous form of the proerythroblast, i.e., the immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." []
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 HP:0025196 Increased total iron binding capacity "An elevation in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. A high TIBC corresponds to a high transferrin concentration. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity." [PMID:3542299]
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 HP:0025354 Abnormal cellular phenotype "An anomaly of cellular morphology or physiology." []
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 HP:0030140 Oral cavity bleeding "Recurrent or excessive bleeding from the mouth." [HPO:cmiller]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000161800 Q9H0H5 / RACGAP1 / Rac GTPase activating protein 1  / reaction / complex
 ENSG00000137807 KIF23 / Q02241 / kinesin family member 23  / complex / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction






 

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contact: otassy@igbmc.fr