ENSG00000121621


Homo sapiens

Features
Gene ID: ENSG00000121621
  
Biological name :KIF18A
  
Synonyms : KIF18A / kinesin family member 18A / Q8NI77
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p14.1
Gene start: 28020620
Gene end: 28108308
  
Corresponding Affymetrix probe sets: 221258_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263181
NCBI entrez gene - 81930     See in Manteia.
OMIM - 611271
RefSeq - NM_031217
RefSeq - XM_017018379
RefSeq Peptide - NP_112494
swissprot - Q8NI77
Ensembl - ENSG00000121621
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif18aENSDARG00000008022Danio rerio
 KIF18AENSGALG00000012160Gallus gallus
 Kif18aENSMUSG00000027115Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIF18B / Q86Y91 / kinesin family member 18BENSG0000018618536
KIF19 / Q2TAC6 / kinesin family member 19ENSG0000019616927
KIF24 / Q5T7B8 / kinesin family member 24ENSG0000018663821
KIF20B / Q96Q89 / kinesin family member 20BENSG0000013818221
KIF22 / Q14807 / kinesin family member 22ENSG0000007961620
KIF23 / Q02241 / kinesin family member 23ENSG0000013780719
KIF2A / O00139 / kinesin family member 2AENSG0000006879616
KIF2C / Q99661 / kinesin family member 2CENSG0000014294516
KIF2B / Q8N4N8 / kinesin family member 2BENSG0000014120015
KIF20A / O95235 / kinesin family member 20AENSG0000011298415


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007019 microtubule depolymerization IDA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0007140 male meiotic nuclear division IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0072520 seminiferous tubule development IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005828 kinetochore microtubule IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:1990023 mitotic spindle midzone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IDA
 molecular_functionGO:0051010 microtubule plus-end binding IDA
 molecular_functionGO:0070463 tubulin-dependent ATPase activity IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121621 KIF18A / Q8NI77 / kinesin family member 18A  / complex / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
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