ENSMUSG00000027115


Mus musculus

Features
Gene ID: ENSMUSG00000027115
  
Biological name :Kif18a
  
Synonyms : Kif18a / Kinesin-like protein KIF18A / Q91WD7
  
Possible biological names infered from orthology : kinesin family member 18A / Q8NI77
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E3
Gene start: 109280738
Gene end: 109341747
  
Corresponding Affymetrix probe sets: 10474381 (MoGene1.0st)   1424107_at (Mouse Genome 430 2.0 Array)   1457895_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028527
NCBI entrez gene - 228421     See in Manteia.
MGI - MGI:2446977
RefSeq - NM_139303
RefSeq - XM_006499259
RefSeq Peptide - NP_647464
swissprot - Q91WD7
Ensembl - ENSMUSG00000027115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif18aENSDARG00000008022Danio rerio
 KIF18AENSGALG00000012160Gallus gallus
 KIF18AENSG00000121621Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif18b / Q6PFD6 / Kinesin-like protein KIF18B / Q86Y91* / kinesin family member 18B*ENSMUSG0000005137834
Q99PT9 / Kif19a / Kinesin-like protein KIF19 / KIF19* / Q2TAC6* / kinesin family member 19*ENSMUSG0000001002127
Gm4869ENSMUSG0000010635024
Kif20b / Q80WE4 / Kinesin-like protein KIF20B / Q96Q89* / kinesin family member 20B*ENSMUSG0000002479521
Kif24 / Q6NWW5 / Kinesin-like protein KIF24 / Q5T7B8* / kinesin family member 24*ENSMUSG0000002843821
Kif22 / Q3V300 / Kinesin-like protein KIF22 / Q14807* / kinesin family member 22*ENSMUSG0000003067720
Kif23 / E9Q5G3 / Kinesin-like protein KIF23 / Q02241* / kinesin family member 23*ENSMUSG0000003225418
Kif2a / P28740 / Kinesin-like protein KIF2A / O00139* / kinesin family member 2A*ENSMUSG0000002169318
Kif2c / Q922S8 / Kinesin-like protein KIF2C / Q99661* / kinesin family member 2C*ENSMUSG0000002867817
Kif2b / Q8C0N1 / Kinesin-like protein KIF2B / Q8N4N8* / kinesin family member 2B*ENSMUSG0000004675516
Kif20a / P97329 / Kinesin-like protein KIF20A / O95235* / kinesin family member 20A*ENSMUSG0000000377915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IBA
 biological_processGO:0007019 microtubule depolymerization IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IMP
 biological_processGO:0072520 seminiferous tubule development IMP
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005828 kinetochore microtubule IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:1990023 mitotic spindle midzone IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003777 microtubule motor activity IBA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0051010 microtubule plus-end binding IEA
 molecular_functionGO:0070463 tubulin-dependent ATPase activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: B6.129S1-Kif18agcd2/JcsJ

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: B6.129S1-Kif18agcd2/JcsJ

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: B6.129S1-Kif18agcd2/JcsJ

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027115 Kif18a / Q91WD7 / Kinesin-like protein KIF18A / Q8NI77* / kinesin family member 18A*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr