ENSMUSG00000024795


Mus musculus

Features
Gene ID: ENSMUSG00000024795
  
Biological name :Kif20b
  
Synonyms : Kif20b / Kinesin-like protein KIF20B / Q80WE4
  
Possible biological names infered from orthology : kinesin family member 20B / Q96Q89
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 34922361
Gene end: 34975745
  
Corresponding Affymetrix probe sets: 10462632 (MoGene1.0st)   1419792_at (Mouse Genome 430 2.0 Array)   1439695_a_at (Mouse Genome 430 2.0 Array)   1440924_at (Mouse Genome 430 2.0 Array)   1449612_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084599
Ensembl peptide - ENSMUSP00000153592
Ensembl peptide - ENSMUSP00000153193
Ensembl peptide - ENSMUSP00000153181
Ensembl peptide - ENSMUSP00000153034
Ensembl peptide - ENSMUSP00000153020
Ensembl peptide - ENSMUSP00000152994
NCBI entrez gene - 240641     See in Manteia.
MGI - MGI:2444576
RefSeq - XM_006527082
RefSeq - XM_006527083
RefSeq - XM_006527084
RefSeq - XM_006527085
RefSeq - XM_006527086
RefSeq - XM_011247247
RefSeq - NM_183046
RefSeq - XM_006527080
RefSeq - XM_006527081
RefSeq Peptide - NP_898867
swissprot - Q80WE4
swissprot - A0A286YE94
swissprot - A0A286YCY3
swissprot - A0A286YCY2
swissprot - A0A286YCJ8
swissprot - A0A286YCI2
swissprot - B7ZWN1
Ensembl - ENSMUSG00000024795
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif20baENSDARG00000071009Danio rerio
 kif20bbENSDARG00000040110Danio rerio
 ENSGALG00000038416Gallus gallus
 ENSGALG00000038799Gallus gallus
 ENSGALG00000034232Gallus gallus
 KIF20BENSG00000138182Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif20a / P97329 / Kinesin-like protein KIF20A / O95235* / kinesin family member 20A*ENSMUSG0000000377917
Kif18a / Q91WD7 / Kinesin-like protein KIF18A / Q8NI77* / kinesin family member 18A*ENSMUSG0000002711511
Kif24 / Q6NWW5 / Kinesin-like protein KIF24 / Q5T7B8* / kinesin family member 24*ENSMUSG0000002843811
Kif23 / E9Q5G3 / Kinesin-like protein KIF23 / Q02241* / kinesin family member 23*ENSMUSG0000003225411
Q99PT9 / Kif19a / Kinesin-like protein KIF19 / KIF19* / Q2TAC6* / kinesin family member 19*ENSMUSG0000001002110
Gm4869ENSMUSG000001063509
Kif22 / Q3V300 / Kinesin-like protein KIF22 / Q14807* / kinesin family member 22*ENSMUSG000000306779
Kif18b / Q6PFD6 / Kinesin-like protein KIF18B / Q86Y91* / kinesin family member 18B*ENSMUSG000000513789
Kif2c / Q922S8 / Kinesin-like protein KIF2C / Q99661* / kinesin family member 2C*ENSMUSG000000286788
Kif2a / P28740 / Kinesin-like protein KIF2A / O00139* / kinesin family member 2A*ENSMUSG000000216937
Kif2b / Q8C0N1 / Kinesin-like protein KIF2B / Q8N4N8* / kinesin family member 2B*ENSMUSG000000467557


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR028828  Kinesin-like protein KIF20B
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0035372 protein localization to microtubule IMP
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070201 regulation of establishment of protein localization IDA
 biological_processGO:0090316 positive regulation of intracellular protein transport IMP
 biological_processGO:1903438 positive regulation of mitotic cytokinetic process IMP
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 biological_processGO:2001222 regulation of neuron migration IGI
 biological_processGO:2001224 positive regulation of neuron migration IMP
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0051233 spindle midzone IDA
 cellular_componentGO:0070938 contractile ring ISS
 cellular_componentGO:0097431 mitotic spindle pole ISS
 cellular_componentGO:1990023 mitotic spindle midzone ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed ISO
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0050699 WW domain binding ISO


Pathways (from Reactome)
Pathway description
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Kif20b33cex/Kif20bmagoo
Genetic Background: involves: BALB/c * C3HeB/FeJ * C57BL/6 * FVB/N

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Kif20b33cex/Kif20bmagoo
Genetic Background: involves: BALB/c * C3HeB/FeJ * C57BL/6 * FVB/N

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003451 absent olfactory bulb "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008442 disorganized cortical plate "derangement of the patterned arrangement of the cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0010714 coloboma of the iris "congenital defect of the iris in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kif20b33cex/Kif20bmagoo
Genetic Background: involves: BALB/c * C3HeB/FeJ * C57BL/6 * FVB/N

 MP:0020337 abnormal pyramidal neuron dendrite morphology "structural anomaly of the highly branched tree-like process of the neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_0000598, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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