ENSMUSG00000021693


Mus musculus

Features
Gene ID: ENSMUSG00000021693
  
Biological name :Kif2a
  
Synonyms : Kif2a / Kinesin-like protein KIF2A / P28740
  
Possible biological names infered from orthology : kinesin family member 2A / O00139
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.1
Gene start: 106958996
Gene end: 107022126
  
Corresponding Affymetrix probe sets: 10412011 (MoGene1.0st)   1432072_at (Mouse Genome 430 2.0 Array)   1450052_at (Mouse Genome 430 2.0 Array)   1450053_at (Mouse Genome 430 2.0 Array)   1452499_a_at (Mouse Genome 430 2.0 Array)   1454107_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112715
Ensembl peptide - ENSMUSP00000116070
Ensembl peptide - ENSMUSP00000022204
Ensembl peptide - ENSMUSP00000125644
Ensembl peptide - ENSMUSP00000113361
Ensembl peptide - ENSMUSP00000113921
NCBI entrez gene - 16563     See in Manteia.
MGI - MGI:108390
RefSeq - XM_006517537
RefSeq - XM_006517535
RefSeq - XM_006517538
RefSeq - NM_001145779
RefSeq - NM_008442
RefSeq - XM_006517539
RefSeq Peptide - NP_032468
RefSeq Peptide - NP_001139251
swissprot - P28740
swissprot - F6RLL5
swissprot - E0CZ72
swissprot - F8VQ42
Ensembl - ENSMUSG00000021693
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KIF2AENSDARG00000043571Danio rerio
 KIF2AENSGALG00000014737Gallus gallus
 KIF2AENSG00000068796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif2c / Q922S8 / Kinesin-like protein KIF2C / Q99661* / kinesin family member 2C*ENSMUSG0000002867852
Kif2b / Q8C0N1 / Kinesin-like protein KIF2B / Q8N4N8* / kinesin family member 2B*ENSMUSG0000004675551
Kif24 / Q6NWW5 / Kinesin-like protein KIF24 / Q5T7B8* / kinesin family member 24*ENSMUSG0000002843834
Kif18a / Q91WD7 / Kinesin-like protein KIF18A / Q8NI77* / kinesin family member 18A*ENSMUSG0000002711522
Q99PT9 / Kif19a / Kinesin-like protein KIF19 / KIF19* / Q2TAC6* / kinesin family member 19*ENSMUSG0000001002121
Gm4869ENSMUSG0000010635020
Kif18b / Q6PFD6 / Kinesin-like protein KIF18B / Q86Y91* / kinesin family member 18B*ENSMUSG0000005137819
Kif20b / Q80WE4 / Kinesin-like protein KIF20B / Q96Q89* / kinesin family member 20B*ENSMUSG0000002479518
Kif23 / E9Q5G3 / Kinesin-like protein KIF23 / Q02241* / kinesin family member 23*ENSMUSG0000003225418
Kif22 / Q3V300 / Kinesin-like protein KIF22 / Q14807* / kinesin family member 22*ENSMUSG0000003067716
Kif20a / P97329 / Kinesin-like protein KIF20A / O95235* / kinesin family member 20A*ENSMUSG0000000377915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030334 regulation of cell migration ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090307 mitotic spindle assembly ISS
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005814 centriole ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule ISS
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0097228 sperm principal piece IDA
 cellular_componentGO:0120103 centriolar subdistal appendage ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000848 abnormal pons "malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000906 abnormal mesencephalic trigeminal nucleus "malformation or disorganization of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0003684 abnormal inferior olivary complex "any structural abnormality in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0006100 abnormal tegmentum morphology "any structural alterations or malfunction of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0020560 abnormal pontine nuclei morphology "any structural anomaly of nuclei in the basal pons, intermingled among the descending axons from the cortex, that receive neocortcial input and give rise to many axons that cross the midline to enter the contralateral cerebellum" [UBERON:0002151]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021693 Kif2a / P28740 / Kinesin-like protein KIF2A / O00139* / kinesin family member 2A*  / complex / reaction
 ENSMUSG00000046755 Kif2b / Q8C0N1 / Kinesin-like protein KIF2B / Q8N4N8* / kinesin family member 2B*  / reaction
 ENSMUSG00000028678 Kif2c / Q922S8 / Kinesin-like protein KIF2C / Q99661* / kinesin family member 2C*  / reaction






 

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