ENSG00000161800


Homo sapiens

Features
Gene ID: ENSG00000161800
  
Biological name :RACGAP1
  
Synonyms : Q9H0H5 / RACGAP1 / Rac GTPase activating protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.12
Gene start: 49976923
Gene end: 50033136
  
Corresponding Affymetrix probe sets: 222077_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450064
Ensembl peptide - ENSP00000449963
Ensembl peptide - ENSP00000450074
Ensembl peptide - ENSP00000309871
Ensembl peptide - ENSP00000404190
Ensembl peptide - ENSP00000404808
Ensembl peptide - ENSP00000446642
Ensembl peptide - ENSP00000446889
Ensembl peptide - ENSP00000447177
Ensembl peptide - ENSP00000447393
Ensembl peptide - ENSP00000447429
Ensembl peptide - ENSP00000448136
Ensembl peptide - ENSP00000448507
Ensembl peptide - ENSP00000448697
Ensembl peptide - ENSP00000448707
Ensembl peptide - ENSP00000448860
Ensembl peptide - ENSP00000448968
Ensembl peptide - ENSP00000449170
Ensembl peptide - ENSP00000449186
Ensembl peptide - ENSP00000449370
Ensembl peptide - ENSP00000449374
Ensembl peptide - ENSP00000449565
Ensembl peptide - ENSP00000449574
Ensembl peptide - ENSP00000449620
Ensembl peptide - ENSP00000449669
Ensembl peptide - ENSP00000449959
NCBI entrez gene - 29127     See in Manteia.
OMIM - 604980
RefSeq - XM_017019227
RefSeq - NM_001126103
RefSeq - NM_001126104
RefSeq - NM_001319999
RefSeq - NM_001320000
RefSeq - NM_001320001
RefSeq - NM_001320002
RefSeq - NM_001320003
RefSeq - NM_001320004
RefSeq - NM_001320005
RefSeq - NM_001320006
RefSeq - NM_001320007
RefSeq - NM_013277
RefSeq - XM_006719359
RefSeq - XM_011538238
RefSeq - XM_011538243
RefSeq - XM_017019220
RefSeq - XM_017019221
RefSeq - XM_017019222
RefSeq - XM_017019223
RefSeq - XM_017019224
RefSeq - XM_017019225
RefSeq - XM_017019226
RefSeq Peptide - NP_001306929
RefSeq Peptide - NP_001306930
RefSeq Peptide - NP_001306931
RefSeq Peptide - NP_001306932
RefSeq Peptide - NP_001306933
RefSeq Peptide - NP_001306934
RefSeq Peptide - NP_001306935
RefSeq Peptide - NP_001306936
RefSeq Peptide - NP_037409
RefSeq Peptide - NP_001119575
RefSeq Peptide - NP_001119576
RefSeq Peptide - NP_001306928
swissprot - H0YIK5
swissprot - F8VQF5
swissprot - F8VQZ5
swissprot - F8VRD2
swissprot - F8VRL2
swissprot - F8VS54
swissprot - F8VUW9
swissprot - F8VV37
swissprot - F8VV39
swissprot - F8VV47
swissprot - F8VVE5
swissprot - F8VVY0
swissprot - F8VWX0
swissprot - F8VWY4
swissprot - F8VXH1
swissprot - F8VYH6
swissprot - F8VZ41
swissprot - F8VZ66
swissprot - F8W0L1
swissprot - F8W1E5
swissprot - Q9H0H5
swissprot - A0A024R136
swissprot - F8W1T4
Ensembl - ENSG00000161800
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 racgap1ENSDARG00000015460Danio rerio
 RACGAP1ENSGALG00000033231Gallus gallus
 Q9WVM1ENSMUSG00000023015Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92619 / ARHGAP45 / Rho GTPase activating protein 45ENSG0000018044819
GMIP / Q9P107 / GEM interacting proteinENSG0000008963919
Q52LW3 / ARHGAP29 / Rho GTPase activating protein 29ENSG0000013796219
A7KAX9 / ARHGAP32 / Rho GTPase activating protein 32ENSG0000013490916
OPHN1 / O60890 / oligophrenin 1ENSG0000007948215
A6NI28 / Q9H2Q1 / ARHGAP42 / Rho GTPase activating protein 42ENSG0000016589514
O14559 / ARHGAP33 / Rho GTPase activating protein 33ENSG0000000477714
Q9UNA1 / ARHGAP26 / Rho GTPase activating protein 26ENSG0000014581914
A1A4S6 / ARHGAP10 / Rho GTPase activating protein 10ENSG0000007120514
Q2M1Z3 / ARHGAP31 / Rho GTPase activating protein 31ENSG0000003108113
Q7Z6I6 / ARHGAP30 / Rho GTPase activating protein 30ENSG0000018651712
Q15311 / RALBP1 / ralA binding protein 1ENSG0000001779712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0000915 actomyosin contractile ring assembly IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEP
 biological_processGO:0007405 neuroblast proliferation ISS
 biological_processGO:0008272 sulfate transport IDA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045995 regulation of embryonic development ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051256 mitotic spindle midzone assembly IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore IMP
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0051233 spindle midzone IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072686 mitotic spindle IMP
 cellular_componentGO:0090543 Flemming body IEA
 cellular_componentGO:0097149 centralspindlin complex IDA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043014 alpha-tubulin binding IDA
 molecular_functionGO:0043015 gamma-tubulin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IDA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137807 KIF23 / Q02241 / kinesin family member 23  / reaction / complex
 ENSG00000161800 Q9H0H5 / RACGAP1 / Rac GTPase activating protein 1  / reaction / complex






 

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