ENSG00000165895


Homo sapiens

Features
Gene ID: ENSG00000165895
  
Biological name :ARHGAP42
  
Synonyms : A6NI28 / ARHGAP42 / Q9H2Q1 / Rho GTPase activating protein 42
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q22.1
Gene start: 100687653
Gene end: 100993941
  
Corresponding Affymetrix probe sets: 1553383_at (Human Genome U133 Plus 2.0 Array)   223595_at (Human Genome U133 Plus 2.0 Array)   230047_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435961
Ensembl peptide - ENSP00000303999
Ensembl peptide - ENSP00000431776
Ensembl peptide - ENSP00000434304
Ensembl peptide - ENSP00000298815
NCBI entrez gene - 143872     See in Manteia.
OMIM - 615936
RefSeq - XM_017017238
RefSeq - NM_032021
RefSeq - NM_152432
RefSeq - XM_011542615
RefSeq - XM_011542616
RefSeq - XM_011542617
RefSeq - XM_017017237
RefSeq Peptide - NP_689645
RefSeq Peptide - NP_114410
swissprot - H0YDU1
swissprot - Q9H2Q1
swissprot - A6NI28
swissprot - H0YEJ7
swissprot - E9PJK4
Ensembl - ENSG00000165895
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap42aENSDARG00000056619Danio rerio
 arhgap42bENSDARG00000010654Danio rerio
 ARHGAP42ENSGALG00000017196Gallus gallus
 B2RQE8ENSMUSG00000050730Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A1A4S6 / ARHGAP10 / Rho GTPase activating protein 10ENSG0000007120549
Q9UNA1 / ARHGAP26 / Rho GTPase activating protein 26ENSG0000014581949
OPHN1 / O60890 / oligophrenin 1ENSG0000007948247
Q52LW3 / ARHGAP29 / Rho GTPase activating protein 29ENSG0000013796216
Q92619 / ARHGAP45 / Rho GTPase activating protein 45ENSG0000018044815
A7KAX9 / ARHGAP32 / Rho GTPase activating protein 32ENSG0000013490915
GMIP / Q9P107 / GEM interacting proteinENSG0000008963914
O14559 / ARHGAP33 / Rho GTPase activating protein 33ENSG0000000477713
Q2M1Z3 / ARHGAP31 / Rho GTPase activating protein 31ENSG0000003108113
Q7Z6I6 / ARHGAP30 / Rho GTPase activating protein 30ENSG0000018651711
Q15311 / RALBP1 / ralA binding protein 1ENSG0000001779710
Q9H0H5 / RACGAP1 / Rac GTPase activating protein 1ENSG0000016180010


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR027267  AH/BAR domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:1904694 negative regulation of vascular smooth muscle contraction IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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