ENSG00000071205


Homo sapiens

Features
Gene ID: ENSG00000071205
  
Biological name :ARHGAP10
  
Synonyms : A1A4S6 / ARHGAP10 / Rho GTPase activating protein 10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.23
Gene start: 147732063
Gene end: 148072780
  
Corresponding Affymetrix probe sets: 219431_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422358
Ensembl peptide - ENSP00000336923
NCBI entrez gene - 79658     See in Manteia.
OMIM - 609746
RefSeq - XM_017008602
RefSeq - NM_024605
RefSeq - XM_005263215
RefSeq Peptide - NP_078881
swissprot - H0Y8W5
swissprot - A1A4S6
Ensembl - ENSG00000071205
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap10ENSDARG00000078326Danio rerio
 ARHGAP10ENSGALG00000010031Gallus gallus
 Q6Y5D8ENSMUSG00000037148Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UNA1 / ARHGAP26 / Rho GTPase activating protein 26ENSG0000014581957
A6NI28 / Q9H2Q1 / ARHGAP42 / Rho GTPase activating protein 42ENSG0000016589554
OPHN1 / O60890 / oligophrenin 1ENSG0000007948244
Q52LW3 / ARHGAP29 / Rho GTPase activating protein 29ENSG0000013796218
Q92619 / ARHGAP45 / Rho GTPase activating protein 45ENSG0000018044817
GMIP / Q9P107 / GEM interacting proteinENSG0000008963916
A7KAX9 / ARHGAP32 / Rho GTPase activating protein 32ENSG0000013490915
Q2M1Z3 / ARHGAP31 / Rho GTPase activating protein 31ENSG0000003108113
O14559 / ARHGAP33 / Rho GTPase activating protein 33ENSG0000000477713
Q7Z6I6 / ARHGAP30 / Rho GTPase activating protein 30ENSG0000018651712
Q15311 / RALBP1 / ralA binding protein 1ENSG0000001779712
Q9H0H5 / RACGAP1 / Rac GTPase activating protein 1ENSG0000016180011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR027267  AH/BAR domain superfamily
 IPR035485  GRAF2, SH3 domain
 IPR035486  Rho GTPase-activating protein 10
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Regulation of PAK-2p34 activity by PS-GAP/RHG10


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction






 

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