ENSG00000145819


Homo sapiens

Features
Gene ID: ENSG00000145819
  
Biological name :ARHGAP26
  
Synonyms : ARHGAP26 / Q9UNA1 / Rho GTPase activating protein 26
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.3
Gene start: 142770377
Gene end: 143229011
  
Corresponding Affymetrix probe sets: 205068_s_at (Human Genome U133 Plus 2.0 Array)   205069_s_at (Human Genome U133 Plus 2.0 Array)   215955_x_at (Human Genome U133 Plus 2.0 Array)   226576_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494415
Ensembl peptide - ENSP00000493847
Ensembl peptide - ENSP00000495131
Ensembl peptide - ENSP00000495827
Ensembl peptide - ENSP00000274498
Ensembl peptide - ENSP00000367243
Ensembl peptide - ENSP00000389137
Ensembl peptide - ENSP00000392186
Ensembl peptide - ENSP00000393276
Ensembl peptide - ENSP00000400565
Ensembl peptide - ENSP00000403388
Ensembl peptide - ENSP00000411571
Ensembl peptide - ENSP00000413283
Ensembl peptide - ENSP00000416889
NCBI entrez gene - 23092     See in Manteia.
OMIM - 605370
RefSeq - XM_017009250
RefSeq - NM_001135608
RefSeq - NM_015071
RefSeq - XM_005268398
RefSeq - XM_005268399
RefSeq - XM_005268400
RefSeq - XM_005268402
RefSeq - XM_006714774
RefSeq - XM_011537610
RefSeq - XM_011537611
RefSeq - XM_011537612
RefSeq - XM_017009247
RefSeq - XM_017009248
RefSeq - XM_017009249
RefSeq Peptide - NP_001129080
RefSeq Peptide - NP_001336476
RefSeq Peptide - NP_055886
swissprot - H7BZE1
swissprot - H7BZZ0
swissprot - H7C1J1
swissprot - C9J6V4
swissprot - H7C3P8
swissprot - Q9UNA1
swissprot - A0A0S2Z536
swissprot - H7C205
swissprot - H0Y4P9
swissprot - H0Y835
Ensembl - ENSG00000145819
  
Related genetic diseases (OMIM): 607785 - Leukemia, juvenile myelomonocytic, somatic, 607785
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5ZMW5ENSGALG00000033938Gallus gallus
 Q6ZQ82ENSMUSG00000036452Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A1A4S6 / ARHGAP10 / Rho GTPase activating protein 10ENSG0000007120555
A6NI28 / Q9H2Q1 / ARHGAP42 / Rho GTPase activating protein 42ENSG0000016589553
OPHN1 / O60890 / oligophrenin 1ENSG0000007948243
Q92619 / ARHGAP45 / Rho GTPase activating protein 45ENSG0000018044816
Q52LW3 / ARHGAP29 / Rho GTPase activating protein 29ENSG0000013796216
A7KAX9 / ARHGAP32 / Rho GTPase activating protein 32ENSG0000013490916
GMIP / Q9P107 / GEM interacting proteinENSG0000008963914
Q2M1Z3 / ARHGAP31 / Rho GTPase activating protein 31ENSG0000003108113
Q15311 / RALBP1 / ralA binding protein 1ENSG0000001779712
O14559 / ARHGAP33 / Rho GTPase activating protein 33ENSG0000000477712
Q9H0H5 / RACGAP1 / Rac GTPase activating protein 1ENSG0000016180011
Q7Z6I6 / ARHGAP30 / Rho GTPase activating protein 30ENSG0000018651711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR027267  AH/BAR domain superfamily
 IPR030061  Rho GTPase-activating protein 26
 IPR035481  GRAF, SH3 domain
 IPR035483  GRAF, BAR domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding IDA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001428 Somatic mutation 
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 HP:0012209 Juvenile myelomonocytic leukemia "Juvenile myelomonocytic leukemia (JMML) is a lethal myeloproliferative disease of young childhood characterized clinically by overproduction of myelomonocytic cells and by the in vitro phenotype of hematopoietic progenitor hypersensitivity to granulocyte-macrophage colony-stimulating factor." [HPO:probinson, pmid:18954903]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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