ENSG00000180448


Homo sapiens

Features
Gene ID: ENSG00000180448
  
Biological name :ARHGAP45
  
Synonyms : ARHGAP45 / Q92619 / Rho GTPase activating protein 45
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 1065923
Gene end: 1086628
  
Corresponding Affymetrix probe sets: 212873_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468615
Ensembl peptide - ENSP00000468607
Ensembl peptide - ENSP00000484008
Ensembl peptide - ENSP00000316772
Ensembl peptide - ENSP00000438979
Ensembl peptide - ENSP00000439601
Ensembl peptide - ENSP00000466365
Ensembl peptide - ENSP00000466401
Ensembl peptide - ENSP00000467741
NCBI entrez gene - 23526     See in Manteia.
OMIM - 601155
RefSeq - XM_011527860
RefSeq - NM_001258328
RefSeq - NM_001282334
RefSeq - NM_001282335
RefSeq - NM_001321232
RefSeq - NM_012292
RefSeq - XM_006722713
RefSeq - XM_011527858
RefSeq Peptide - NP_001308161
RefSeq Peptide - NP_036424
RefSeq Peptide - NP_001245257
RefSeq Peptide - NP_001269263
RefSeq Peptide - NP_001269264
swissprot - K7ES98
swissprot - F5H1R4
swissprot - K7EM55
swissprot - K7EM85
swissprot - K7EQA4
swissprot - Q92619
swissprot - A0A087X1A3
swissprot - K7ES92
Ensembl - ENSG00000180448
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmha1aENSDARG00000052496Danio rerio
 hmha1bENSDARG00000062049Danio rerio
 ARHGAP45ENSGALG00000032469Gallus gallus
 Q3TBD2ENSMUSG00000035697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q52LW3 / ARHGAP29 / Rho GTPase activating protein 29ENSG0000013796232
GMIP / Q9P107 / GEM interacting proteinENSG0000008963927
A7KAX9 / ARHGAP32 / Rho GTPase activating protein 32ENSG0000013490913
A6NI28 / Q9H2Q1 / ARHGAP42 / Rho GTPase activating protein 42ENSG0000016589512
O14559 / ARHGAP33 / Rho GTPase activating protein 33ENSG0000000477711
Q9UNA1 / ARHGAP26 / Rho GTPase activating protein 26ENSG0000014581911
OPHN1 / O60890 / oligophrenin 1ENSG0000007948211
A1A4S6 / ARHGAP10 / Rho GTPase activating protein 10ENSG0000007120511
Q9H0H5 / RACGAP1 / Rac GTPase activating protein 1ENSG0000016180010
Q15311 / RALBP1 / ralA binding protein 1ENSG000000177979
Q2M1Z3 / ARHGAP31 / Rho GTPase activating protein 31ENSG000000310818
Q7Z6I6 / ARHGAP30 / Rho GTPase activating protein 30ENSG000001865178


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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