ENSMUSG00000037148


Mus musculus

Features
Gene ID: ENSMUSG00000037148
  
Biological name :Arhgap10
  
Synonyms : Arhgap10 / Q6Y5D8 / Rho GTPase-activating protein 10
  
Possible biological names infered from orthology : A1A4S6
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C1
Gene start: 77250366
Gene end: 77517953
  
Corresponding Affymetrix probe sets: 10579776 (MoGene1.0st)   1426027_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075658
Ensembl peptide - ENSMUSP00000147485
Ensembl peptide - ENSMUSP00000147493
NCBI entrez gene - 78514     See in Manteia.
MGI - MGI:1925764
RefSeq - XM_017313021
RefSeq - NM_030113
RefSeq - XM_017313019
RefSeq - XM_017313020
RefSeq - XM_006531495
RefSeq - XM_006531498
RefSeq - XM_006531500
RefSeq - XM_011248553
RefSeq - XM_017313014
RefSeq - XM_017313015
RefSeq - XM_017313016
RefSeq - XM_017313017
RefSeq - XM_017313018
RefSeq Peptide - NP_084389
swissprot - Q6Y5D8
Ensembl - ENSMUSG00000037148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap10ENSDARG00000078326Danio rerio
 ARHGAP10ENSGALG00000010031Gallus gallus
 A1A4S6ENSG00000071205Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZQ82 / Arhgap26 / Rho GTPase activating protein 26 / Q9UNA1*ENSMUSG0000003645256
B2RQE8 / Arhgap42 / Rho GTPase activating protein 42 / A6NI28* / Q9H2Q1*ENSMUSG0000005073050
Ophn1 / Q99J31 / Oligophrenin-1 / O60890*ENSMUSG0000003121442
Q8CGF1 / Arhgap29 / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript variant 2, mRNA. / Q52LW3* / Rho GTPase activating protein 29*ENSMUSG0000003983117
Q3TBD2 / Arhgap45 / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA. / Q92619* / Rho GTPase activating protein 45*ENSMUSG0000003569716
Q811P8 / Arhgap32 / Rho GTPase-activating protein 32 / A7KAX9*ENSMUSG0000004144415
Gmip / Q6PGG2 / Gem-interacting protein / Q9P107*ENSMUSG0000003624614
Q80YF9 / Arhgap33 / Rho GTPase-activating protein 33 / O14559*ENSMUSG0000003688214
Q62172 / Ralbp1 / ralA binding protein 1 / Q15311*ENSMUSG0000002409613
A6X8Z5 / Arhgap31 / Rho GTPase activating protein 31 / Q2M1Z3*ENSMUSG0000002279913
Arhgap30 / Rho GTPase activating protein 30 / Q7Z6I6*ENSMUSG0000004886512
Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1 / Q9H0H5*ENSMUSG0000002301510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR027267  AH/BAR domain superfamily
 IPR035485  GRAF2, SH3 domain
 IPR035486  Rho GTPase-activating protein 10
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity IPI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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