ENSMUSG00000041444


Mus musculus

Features
Gene ID: ENSMUSG00000041444
  
Biological name :Arhgap32
  
Synonyms : Arhgap32 / Q811P8 / Rho GTPase-activating protein 32
  
Possible biological names infered from orthology : A7KAX9
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A4
Gene start: 32116136
Gene end: 32268446
  
Corresponding Affymetrix probe sets: 10584124 (MoGene1.0st)   1438451_at (Mouse Genome 430 2.0 Array)   1453709_at (Mouse Genome 430 2.0 Array)   1457597_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138145
Ensembl peptide - ENSMUSP00000133898
Ensembl peptide - ENSMUSP00000138584
Ensembl peptide - ENSMUSP00000138636
Ensembl peptide - ENSMUSP00000128448
NCBI entrez gene - 330914     See in Manteia.
MGI - MGI:2450166
RefSeq - XM_011242560
RefSeq - NM_001195632
RefSeq - NM_177379
RefSeq - XM_006510442
RefSeq - XM_006510445
RefSeq Peptide - NP_001182561
RefSeq Peptide - NP_796353
swissprot - S4R2C0
swissprot - S4R2G6
swissprot - Q811P8
Ensembl - ENSMUSG00000041444
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap32aENSDARG00000075334Danio rerio
 arhgap32bENSDARG00000074184Danio rerio
 ARHGAP32ENSGALG00000043511Gallus gallus
 A7KAX9ENSG00000134909Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80YF9 / Arhgap33 / Rho GTPase-activating protein 33 / O14559*ENSMUSG0000003688227
A6X8Z5 / Arhgap31 / Rho GTPase activating protein 31 / Q2M1Z3*ENSMUSG0000002279917
Arhgap30 / Rho GTPase activating protein 30 / Q7Z6I6*ENSMUSG0000004886516
Q3TBD2 / Arhgap45 / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA. / Q92619* / Rho GTPase activating protein 45*ENSMUSG000000356977
Q8CGF1 / Arhgap29 / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript variant 2, mRNA. / Q52LW3* / Rho GTPase activating protein 29*ENSMUSG000000398317
Q62172 / Ralbp1 / ralA binding protein 1 / Q15311*ENSMUSG000000240966
Q6Y5D8 / Arhgap10 / Rho GTPase-activating protein 10 / A1A4S6*ENSMUSG000000371486
Q6ZQ82 / Arhgap26 / Rho GTPase activating protein 26 / Q9UNA1*ENSMUSG000000364526
Gmip / Q6PGG2 / Gem-interacting protein / Q9P107*ENSMUSG000000362466
B2RQE8 / Arhgap42 / Rho GTPase activating protein 42 / A6NI28* / Q9H2Q1*ENSMUSG000000507306
Ophn1 / Q99J31 / Oligophrenin-1 / O60890*ENSMUSG000000312145
Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1 / Q9H0H5*ENSMUSG000000230155


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001452  SH3 domain
 IPR001683  Phox homologous domain
 IPR008936  Rho GTPase activation protein
 IPR036028  SH3-like domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IBA
 biological_processGO:0007266 Rho protein signal transduction ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0011622 abnormal habituation to a novel odor "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a novel odor" [MGI:csmith]
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Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0012315 impaired learning "impaired ability to aquire lasting change in behavior that is the result of experience" [http:psychology.about.com/od/lindex/g/learning.htm]
Show

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
Show

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0020395 abnormal response to social novelty "any anomaly in the interaction of an individual with a familiar versus a novel individual of the same species; in mouse the typical behavior is is for increased interaction with the novel individual" [PMID:23280234]
Show

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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