ENSMUSG00000039831


Mus musculus

Features
Gene ID: ENSMUSG00000039831
  
Biological name :Arhgap29
  
Synonyms : Arhgap29 / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript variant 2, mRNA. / Q8CGF1
  
Possible biological names infered from orthology : Q52LW3 / Rho GTPase activating protein 29
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 121952541
Gene end: 122016753
  
Corresponding Affymetrix probe sets: 10495685 (MoGene1.0st)   1441618_at (Mouse Genome 430 2.0 Array)   1444512_at (Mouse Genome 430 2.0 Array)   1454745_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142817
Ensembl peptide - ENSMUSP00000143548
Ensembl peptide - ENSMUSP00000143547
Ensembl peptide - ENSMUSP00000143079
Ensembl peptide - ENSMUSP00000142945
Ensembl peptide - ENSMUSP00000044624
NCBI entrez gene - 214137     See in Manteia.
MGI - MGI:2443818
RefSeq - XM_006501290
RefSeq - NM_001356524
RefSeq - NM_172525
RefSeq - XM_006501288
RefSeq - XM_006501289
RefSeq Peptide - NP_001343453
RefSeq Peptide - NP_766113
swissprot - A0A0G2JEL5
swissprot - A0A0G2JGF7
swissprot - Q8CGF1
swissprot - A0A0G2JEY0
swissprot - A0A0G2JGF8
Ensembl - ENSMUSG00000039831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap29aENSDARG00000026329Danio rerio
 arhgap29bENSDARG00000017748Danio rerio
 ARHGAP29ENSGALG00000005683Gallus gallus
 Q52LW3ENSG00000137962Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TBD2 / Arhgap45 / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA. / Q92619* / Rho GTPase activating protein 45*ENSMUSG0000003569729
Gmip / Q6PGG2 / Gem-interacting protein / Q9P107*ENSMUSG0000003624624
Q811P8 / Arhgap32 / Rho GTPase-activating protein 32 / A7KAX9*ENSMUSG0000004144412
Q6Y5D8 / Arhgap10 / Rho GTPase-activating protein 10 / A1A4S6*ENSMUSG0000003714811
Q80YF9 / Arhgap33 / Rho GTPase-activating protein 33 / O14559*ENSMUSG0000003688211
B2RQE8 / Arhgap42 / Rho GTPase activating protein 42 / A6NI28* / Q9H2Q1*ENSMUSG0000005073010
Ophn1 / Q99J31 / Oligophrenin-1 / O60890*ENSMUSG0000003121410
Q6ZQ82 / Arhgap26 / Rho GTPase activating protein 26 / Q9UNA1*ENSMUSG0000003645210
Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1 / Q9H0H5*ENSMUSG0000002301510
Q62172 / Ralbp1 / ralA binding protein 1 / Q15311*ENSMUSG000000240969
A6X8Z5 / Arhgap31 / Rho GTPase activating protein 31 / Q2M1Z3*ENSMUSG000000227999
Arhgap30 / Rho GTPase activating protein 30 / Q7Z6I6*ENSMUSG000000488658


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009884 palatal shelf fusion with tongue or mandible "palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues" [PMID:16680722]
Show

Allelic Composition: Gm36723em3Flv/Gm36723em3Flv
Genetic Background: C57BL/6-Gm36723em3Flv

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Gm36723em3Flv/Gm36723em3Flv
Genetic Background: C57BL/6-Gm36723em3Flv

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Gm36723em3Flv/Gm36723em3Flv
Genetic Background: C57BL/6-Gm36723em3Flv

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29em1(IMPC)J
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

 MP:0013530 abnormal periderm morphology "any structural anomaly of the outermost layer of the bilaminar embryonic/fetal epidermis, the first non-basal layer formed at approximately E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo s physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at approximately E17, when it is replaced by corneocytes; desquamated peridermal cells are a considerable component of the vernix caseosa, a white, cheesy, protective substance that covers the fetal skin" [http://discovery.lifemapsc.com/in-vivo-development/epidermis#section_literature, http://medical-dictionary.thefreedictionary.com/periderm, MGI:Anna]
Show

Allelic Composition: Gm36723em3Flv/Gm36723em3Flv
Genetic Background: C57BL/6-Gm36723em3Flv

 MP:0030179 abnormal oral epithelium morphology "any structural anomaly of the stratified squamous epithelium that forms part of the oral mucosa and lines the inner aspect of the oral cavity; depending on the mouth region, the epithelium may be non-keratinized or keratinized; non-keratinized squamous epithelium covers the soft palate, inner lips, inner cheeks, and the floor of the mouth, and ventral surface of the tongue; keratinized squamous epithelium is present in the attached gingiva and hard palate as well as areas of the dorsal surface of the tongue" [https://en.wikipedia.org/wiki/Oral_mucosa]
Show

Allelic Composition: Gm36723em3Flv/Gm36723em3Flv
Genetic Background: C57BL/6-Gm36723em3Flv

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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