ENSMUSG00000023015


Mus musculus

Features
Gene ID: ENSMUSG00000023015
  
Biological name :Racgap1
  
Synonyms : Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1
  
Possible biological names infered from orthology : Q9H0H5
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 99620496
Gene end: 99651656
  
Corresponding Affymetrix probe sets: 10432511 (MoGene1.0st)   1421546_a_at (Mouse Genome 430 2.0 Array)   1441889_x_at (Mouse Genome 430 2.0 Array)   1451358_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130282
Ensembl peptide - ENSMUSP00000128892
Ensembl peptide - ENSMUSP00000130876
Ensembl peptide - ENSMUSP00000132732
Ensembl peptide - ENSMUSP00000132471
Ensembl peptide - ENSMUSP00000023756
Ensembl peptide - ENSMUSP00000105209
Ensembl peptide - ENSMUSP00000126417
NCBI entrez gene - 26934     See in Manteia.
MGI - MGI:1349423
RefSeq - XM_011245647
RefSeq - NM_001253808
RefSeq - NM_001253809
RefSeq - NM_012025
RefSeq - XM_006521019
RefSeq - XM_006521020
RefSeq - XM_011245646
RefSeq Peptide - NP_001240738
RefSeq Peptide - NP_036155
RefSeq Peptide - NP_001240737
swissprot - F6WD40
swissprot - E9Q1Y6
swissprot - E9Q071
swissprot - Q9WVM1
swissprot - E9Q9N9
swissprot - E9Q851
Ensembl - ENSMUSG00000023015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 racgap1ENSDARG00000015460Danio rerio
 RACGAP1ENSGALG00000033231Gallus gallus
 Q9H0H5ENSG00000161800Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CGF1 / Arhgap29 / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript variant 2, mRNA. / Q52LW3* / Rho GTPase activating protein 29*ENSMUSG0000003983120
Q3TBD2 / Arhgap45 / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA. / Q92619* / Rho GTPase activating protein 45*ENSMUSG0000003569719
Gmip / Q6PGG2 / Gem-interacting protein / Q9P107*ENSMUSG0000003624618
Q80YF9 / Arhgap33 / Rho GTPase-activating protein 33 / O14559*ENSMUSG0000003688216
Q811P8 / Arhgap32 / Rho GTPase-activating protein 32 / A7KAX9*ENSMUSG0000004144415
Ophn1 / Q99J31 / Oligophrenin-1 / O60890*ENSMUSG0000003121415
B2RQE8 / Arhgap42 / Rho GTPase activating protein 42 / A6NI28* / Q9H2Q1*ENSMUSG0000005073013
A6X8Z5 / Arhgap31 / Rho GTPase activating protein 31 / Q2M1Z3*ENSMUSG0000002279913
Q6Y5D8 / Arhgap10 / Rho GTPase-activating protein 10 / A1A4S6*ENSMUSG0000003714813
Q6ZQ82 / Arhgap26 / Rho GTPase activating protein 26 / Q9UNA1*ENSMUSG0000003645213
Q62172 / Ralbp1 / ralA binding protein 1 / Q15311*ENSMUSG0000002409612
Arhgap30 / Rho GTPase activating protein 30 / Q7Z6I6*ENSMUSG0000004886512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis ISO
 biological_processGO:0000915 actomyosin contractile ring assembly ISO
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007405 neuroblast proliferation IEP
 biological_processGO:0008272 sulfate transport ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045995 regulation of embryonic development IMP
 biological_processGO:0051256 mitotic spindle midzone assembly ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore ISO
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032154 cleavage furrow ISO
 cellular_componentGO:0051233 spindle midzone ISO
 cellular_componentGO:0072686 mitotic spindle ISS
 cellular_componentGO:0090543 Flemming body IEA
 cellular_componentGO:0097149 centralspindlin complex ISS
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISO
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0043014 alpha-tubulin binding ISS
 molecular_functionGO:0043015 gamma-tubulin binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048487 beta-tubulin binding ISS


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023015 Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1 / Q9H0H5*  / reaction / complex
 ENSMUSG00000032254 Kif23 / E9Q5G3 / Kinesin-like protein KIF23 / Q02241* / kinesin family member 23*  / complex / reaction






 

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