ENSDARG00000015460


Danio rerio

Features
Gene ID: ENSDARG00000015460
  
Biological name :racgap1
  
Synonyms : racgap1 / Rac GTPase activating protein 1
  
Possible biological names infered from orthology : Q9H0H5 / Q9WVM1
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 33757173
Gene end: 33775309
  
Corresponding Affymetrix probe sets: Dr.18519.1.S1_at (Zebrafish Array)   Dr.733.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000020703
Ensembl peptide - ENSDARP00000141431
Ensembl peptide - ENSDARP00000116910
NCBI entrez gene - 323197     See in Manteia.
swissprot - E9QHH8
swissprot - A0A0R4IZK0
swissprot - Q6P3H8
ZFIN ID - ZDB-GENE-030131-1917
Ensembl - ENSDARG00000015460
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RACGAP1ENSGALG00000033231Gallus gallus
 Q9H0H5ENSG00000161800Homo sapiens
 Q9WVM1ENSMUSG00000023015Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch1073-416j23.1ENSDARG0000005593442
arhgap29b / Rho GTPase activating protein 29b / Q52LW3* / Q8CGF1* / ARHGAP29* / Rho GTPase activating protein 29* / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript vari...ENSDARG0000001774819
arhgap29a / Rho GTPase activating protein 29a / Q52LW3* / Q8CGF1* / ARHGAP29* / Rho GTPase activating protein 29* / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript vari...ENSDARG0000002632918
gmip / GEM interacting protein / Q6PGG2* / Q9P107*ENSDARG0000007724917
hmha1b / histocompatibility (minor) HA-1 b / Q92619* / Q3TBD2* / ARHGAP45* / Rho GTPase activating protein 45* / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA.*ENSDARG0000006204917
hmha1a / histocompatibility (minor) HA-1 a / Q92619* / ARHGAP45* / Rho GTPase activating protein 45*ENSDARG0000005249617
arhgap32a / Rho GTPase activating protein 32a / A7KAX9* / Q811P8* / ARHGAP32* / Rho GTPase activating protein 32*ENSDARG0000007533415
arhgap32b / Rho GTPase activating protein 32b / A7KAX9* / Q811P8* / ARHGAP32* / Rho GTPase activating protein 32*ENSDARG0000007418415
arhgap42a / Rho GTPase activating protein 42a / B2RQE8* / Q9H2Q1* / A6NI28* / ARHGAP42* / Rho GTPase activating protein 42*ENSDARG0000005661914
arhgap42b / Rho GTPase activating protein 42b / A6NI28* / Q9H2Q1* / ARHGAP42* / Rho GTPase activating protein 42*ENSDARG0000001065413
ophn1 / oligophrenin 1 / O60890* / Q99J31*ENSDARG0000003542013
arhgap33 / Rho GTPase activating protein 33 / O14559* / Q80YF9*ENSDARG0000001133313
arhgap10 / Rho GTPase activating protein 10 / A1A4S6* / Q6Y5D8*ENSDARG0000007832612
si:dkeyp-68b7.12 / Q7Z6I6* / ARHGAP30* / Rho GTPase activating protein 30*ENSDARG0000007484611
ralbp1 / ralA binding protein 1 / Q15311*ENSDARG0000007865311
arhgap31 / Rho GTPase activating protein 31 / A6X8Z5* / Q2M1Z3*ENSDARG0000005947210
si:ch73-243b8.4ENSDARG000000951741


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain absent , abnormal
brain degenerate , abnormal
brain decreased amount , abnormal
Show

 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm spatial pattern , abnormal
Show

 ZFA:0000077 tail bud tail bud increased amount , abnormal
tail bud increased distribution , abnormal
tail bud apoptotic , abnormal
Show

 ZFA:0000098 proliferative region proliferative region decreased distribution , abnormal
proliferative region decreased amount , abnormal
Show

 ZFA:0000570 optic primordium optic primordium decreased size , abnormal
Show

 ZFA:0000778 spinal cord interneuron spinal cord interneuron spatial pattern , abnormal
Show

 ZFA:0001094 whole organism whole organism necrotic , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism has extra parts of type embryonic structure nucleus, abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism opacity , abnormal
whole organism cell low brightness , abnormal
whole organism cell spherical , abnormal
whole organism apoptotic process increased occurrence , abnormal
Show

 ZFA:0001114 head head apoptotic , abnormal
head increased amount , abnormal
head increased distribution , abnormal
Show

 ZFA:0001115 trunk trunk increased amount , abnormal
trunk increased distribution , abnormal
trunk apoptotic , abnormal
Show

 ZFA:0001176 blastoderm blastoderm apoptotic process increased occurrence , abnormal
Show

 ZFA:0005176 CoSA CoSA spatial pattern , abnormal
Show

 ZFA:0005768 trigeminal sensory neuron trigeminal sensory neuron spinal sensory neuron axon guidance disrupted , abnormal
Show

 ZFA:0009000 cell cell binucleate , abnormal
cell multinucleate , abnormal
cell knobbled , abnormal
cell mitotic cell cycle decreased amount , abnormal
cell increased size , abnormal
Show

 ZFA:0009011 neuroblast neuroblast decreased distribution , abnormal
neuroblast decreased amount , abnormal
Show

 ZFA:0009044 blood cell blood cell increased size , abnormal
blood cell decreased amount , abnormal
Show

 ZFA:0009053 sensory neuron sensory neuron axon spatial pattern , abnormal
sensory neuron axon disorganized , abnormal
sensory neuron axon distended , abnormal
Show

 ZFA:0009141 macrophage macrophage decreased distribution , abnormal
macrophage decreased amount , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron spatial pattern , abnormal
Rohon-Beard neuron axon disorganized , abnormal
Rohon-Beard neuron spinal sensory neuron axon guidance disrupted , abnormal
Rohon-Beard neuron axon microtubule bundle disorganized , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron spatial pattern , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte spatial pattern , abnormal
nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte mitotic cell cycle increased duration , abnormal
nucleate erythrocyte nucleus increased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil decreased distribution , abnormal
neutrophil decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000015460 racgap1 / Rac GTPase activating protein 1 / Q9H0H5* / Q9WVM1*  / complex / reaction
 ENSDARG00000014943 kif23 / kinesin family member 23 / E9Q5G3* / Q02241* / Kinesin-like protein KIF23 *  / reaction / complex






 

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