ENSMUSG00000024096


Mus musculus

Features
Gene ID: ENSMUSG00000024096
  
Biological name :Ralbp1
  
Synonyms : Q62172 / ralA binding protein 1 / Ralbp1
  
Possible biological names infered from orthology : Q15311
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.1
Gene start: 65848433
Gene end: 65885755
  
Corresponding Affymetrix probe sets: 10452496 (MoGene1.0st)   1417248_at (Mouse Genome 430 2.0 Array)   1448634_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024905
Ensembl peptide - ENSMUSP00000129448
NCBI entrez gene - 19765     See in Manteia.
MGI - MGI:108466
RefSeq - XM_006523915
RefSeq - NM_001198949
RefSeq - NM_009067
RefSeq Peptide - NP_033093
RefSeq Peptide - NP_001185878
swissprot - Q62172
Ensembl - ENSMUSG00000024096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ralbp1ENSDARG00000078653Danio rerio
 RALBP1ENSGALG00000008405Gallus gallus
 Q15311ENSG00000017797Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q811P8 / Arhgap32 / Rho GTPase-activating protein 32 / A7KAX9*ENSMUSG0000004144418
A6X8Z5 / Arhgap31 / Rho GTPase activating protein 31 / Q2M1Z3*ENSMUSG0000002279917
Q8CGF1 / Arhgap29 / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript variant 2, mRNA. / Q52LW3* / Rho GTPase activating protein 29*ENSMUSG0000003983117
Q6Y5D8 / Arhgap10 / Rho GTPase-activating protein 10 / A1A4S6*ENSMUSG0000003714816
Arhgap30 / Rho GTPase activating protein 30 / Q7Z6I6*ENSMUSG0000004886516
Q3TBD2 / Arhgap45 / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA. / Q92619* / Rho GTPase activating protein 45*ENSMUSG0000003569716
Q80YF9 / Arhgap33 / Rho GTPase-activating protein 33 / O14559*ENSMUSG0000003688215
Q6ZQ82 / Arhgap26 / Rho GTPase activating protein 26 / Q9UNA1*ENSMUSG0000003645215
Gmip / Q6PGG2 / Gem-interacting protein / Q9P107*ENSMUSG0000003624614
B2RQE8 / Arhgap42 / Rho GTPase activating protein 42 / A6NI28* / Q9H2Q1*ENSMUSG0000005073013
Ophn1 / Q99J31 / Oligophrenin-1 / O60890*ENSMUSG0000003121413
Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1 / Q9H0H5*ENSMUSG0000002301511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR008936  Rho GTPase activation protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport ISO
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IBA
 biological_processGO:0043087 regulation of GTPase activity ISO
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0055085 transmembrane transport ISO
 biological_processGO:1900753 doxorubicin transport ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IBA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015238 drug transmembrane transporter activity ISO
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0017160 Ral GTPase binding IPI
 molecular_functionGO:0022857 transmembrane transporter activity ISO
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0048365 Rac GTPase binding ISO


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Mpig6btm1.1Arte/Mpig6btm1.1Arte,Gp6tm1Ware/Gp6tm1Ware
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Men1tm1Zqw/Men1tm1Zqw
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Ralbp1Gt(OST359995)Lex/Ralbp1+
Genetic Background: involves: 129S5/SvEvBrd * C57BL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1tm1Zqw
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Ralbp1Gt(OST359995)Lex/Ralbp1+
Genetic Background: involves: 129S5/SvEvBrd * C57BL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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