5347


Homo sapiens (NCBI)

Features
Gene ID: 5347
  
Biological name :
  
Synonyms : PLK1 / PLK|STPK13 / polo like kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 202240_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 21359873
RefSeq - NC_000016.10
RefSeq - NP_005021.2
RefSeq - NM_005030.5
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000166851 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IMP
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0000281 mitotic cytokinesis IDA
 biological_processGO:0001578 microtubule bundle formation IDA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007094 mitotic spindle assembly checkpoint IMP
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0016321 female meiosis chromosome segregation IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IMP
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043393 regulation of protein binding IMP
 biological_processGO:0045143 homologous chromosome segregation IEA
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
 biological_processGO:0045862 positive regulation of proteolysis IDA
 biological_processGO:0051081 nuclear envelope disassembly IMP
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IMP
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0070194 synaptonemal complex disassembly IEA
 biological_processGO:0071168 protein localization to chromatin IDA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IDA
 biological_processGO:0090435 protein localization to nuclear envelope IMP
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1900182 positive regulation of protein localization to nucleus TAS
 biological_processGO:1901673 regulation of mitotic spindle assembly IDA
 biological_processGO:1902749 regulation of cell cycle G2/M phase transition TAS
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity TAS
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0051233 spindle midzone IDA
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IMP
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0010997 anaphase-promoting complex binding IPI
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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