ENSG00000141446


Homo sapiens

Features
Gene ID: ENSG00000141446
  
Biological name :ESCO1
  
Synonyms : ESCO1 / establishment of sister chromatid cohesion N-acetyltransferase 1 / Q5FWF5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q11.2
Gene start: 21529281
Gene end: 21600884
  
Corresponding Affymetrix probe sets: 226866_at (Human Genome U133 Plus 2.0 Array)   235216_at (Human Genome U133 Plus 2.0 Array)   235645_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000269214
Ensembl peptide - ENSP00000484873
Ensembl peptide - ENSP00000372763
NCBI entrez gene - 114799     See in Manteia.
OMIM - 609674
RefSeq - XM_011525798
RefSeq - XM_011525799
RefSeq - NM_052911
RefSeq Peptide - NP_443143
swissprot - Q5FWF5
swissprot - A0A0C4DH04
swissprot - A0A024RC19
Ensembl - ENSG00000141446
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esco1ENSDARG00000077057Danio rerio
 ESCO1ENSGALG00000014936Gallus gallus
 Esco1ENSMUSG00000024293Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ESCO2 / Q56NI9 / establishment of sister chromatid cohesion N-acetyltransferase 2ENSG0000017132021


Protein motifs (from Interpro)
Interpro ID Name
 IPR026656  N-acetyltransferase ESCO1
 IPR028005  N-acetyltransferase ESCO, zinc-finger
 IPR028009  N-acetyltransferase ESCO, acetyl-transferase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0018394 peptidyl-lysine acetylation IDA
 biological_processGO:0034421 post-translational protein acetylation IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0008080 N-acetyltransferase activity TAS
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061733 peptide-lysine-N-acetyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Establishment of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000062650 WAPL / Q7Z5K2 / WAPL cohesin release factor  / reaction
 ENSG00000083642 PDS5B / Q9NTI5 / PDS5 cohesin associated factor B  / reaction
 ENSG00000121892 PDS5A / Q29RF7 / PDS5 cohesin associated factor A  / reaction






 

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