ENSMUSG00000024293


Mus musculus

Features
Gene ID: ENSMUSG00000024293
  
Biological name :Esco1
  
Synonyms : Esco1 / N-acetyltransferase ESCO1 / Q69Z69
  
Possible biological names infered from orthology : establishment of sister chromatid cohesion N-acetyltransferase 1 / Q5FWF5
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 10566602
Gene end: 10610352
  
Corresponding Affymetrix probe sets: 10407040 (MoGene1.0st)   10457465 (MoGene1.0st)   1424324_at (Mouse Genome 430 2.0 Array)   1424325_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025142
Ensembl peptide - ENSMUSP00000095274
Ensembl peptide - ENSMUSP00000111530
NCBI entrez gene - 77805     See in Manteia.
MGI - MGI:1925055
RefSeq - XM_006526353
RefSeq - NM_001081222
RefSeq Peptide - NP_001074691
swissprot - Q3UKT9
swissprot - Q69Z69
Ensembl - ENSMUSG00000024293
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esco1ENSDARG00000077057Danio rerio
 ESCO1ENSGALG00000014936Gallus gallus
 ESCO1ENSG00000141446Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Esco2 / Q8CIB9 / N-acetyltransferase ESCO2 / Q56NI9* / establishment of sister chromatid cohesion N-acetyltransferase 2*ENSMUSG0000002203421


Protein motifs (from Interpro)
Interpro ID Name
 IPR026656  N-acetyltransferase ESCO1
 IPR028005  N-acetyltransferase ESCO, zinc-finger
 IPR028009  N-acetyltransferase ESCO, acetyl-transferase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006275 regulation of DNA replication ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0018394 peptidyl-lysine acetylation ISO
 biological_processGO:0034421 post-translational protein acetylation ISO
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0008080 N-acetyltransferase activity ISS
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061733 peptide-lysine-N-acetyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Establishment of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / reaction
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction






 

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