ENSGALG00000036892


Gallus gallus

Features
Gene ID: ENSGALG00000036892
  
Biological name :BUB1B
  
Synonyms : BUB1B / BUB1 mitotic checkpoint serine/threonine kinase B
  
Possible biological names infered from orthology : Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / O60566 / Q9Z1S0
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 558497
Gene end: 582785
  
Corresponding Affymetrix probe sets: Gga.8462.1.S1_at (Chicken Array)   Gga.9522.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055351
Ensembl peptide - ENSGALP00000061891
NCBI entrez gene - 378922     See in Manteia.
RefSeq - NM_204403
RefSeq Peptide - NP_989734
swissprot - A0A1L1RSW6
swissprot - A0A1D5PR30
Ensembl - ENSGALG00000036892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bub1bbENSDARG00000074927Danio rerio
 BUB1BENSG00000156970Homo sapiens
 Bub1bENSMUSG00000040084Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BUB1 / mitotic checkpoint serine/threonine-protein kinase BUB1 / O43683* / BUB1 mitotic checkpoint serine/threonine kinase* / mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2 *ENSGALG0000000823318


Protein motifs (from Interpro)
Interpro ID Name
 IPR011009  Protein kinase-like domain superfamily
 IPR013212  Mad3/Bub1 homology region 1
 IPR015661  Mitotic spindle checkpoint protein Bub1/Mad3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007091 metaphase/anaphase transition of mitotic cell cycle IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0034501 protein localization to kinetochore IEA
 biological_processGO:0071459 protein localization to chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IEA
 cellular_componentGO:0000940 condensed chromosome outer kinetochore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003085 CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*  / complex / reaction
 ENSGALG00000009971 CDC20 / cell division cycle 20 / Q12834* / Q9JJ66* / Cell division cycle *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000009681 BUB3 / BUB3, mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / complex / reaction






 

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