ENSDARG00000075883


Danio rerio

Features
Gene ID: ENSDARG00000075883
  
Biological name :bub3
  
Synonyms : bub3 / BUB3 mitotic checkpoint protein
  
Possible biological names infered from orthology : Mitotic checkpoint protein BUB3 / O43684 / Q9WVA3
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 49146715
Gene end: 49151326
  
Corresponding Affymetrix probe sets: Dr.4431.1.A1_at (Zebrafish Array)   Dr.4431.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000127247
Ensembl peptide - ENSDARP00000151878
NCBI entrez gene - 403012     See in Manteia.
swissprot - Q6TNV6
swissprot - U3JAH9
ZFIN ID - ZDB-GENE-041010-210
Ensembl - ENSDARG00000075883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BUB3ENSGALG00000009681Gallus gallus
 BUB3ENSG00000154473Homo sapiens
 Bub3ENSMUSG00000066979Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rae1 / Q7ZWF0 / ribonucleic acid export 1 / P78406*ENSDARG0000000719633


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007094 mitotic spindle assembly checkpoint IBA
 cellular_componentGO:0000776 kinetochore IBA
 cellular_componentGO:0033597 mitotic checkpoint complex IBA
 cellular_componentGO:1990298 bub1-bub3 complex IBA
 molecular_functionGO:0043130 ubiquitin binding IBA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005619 nek2 / NIMA-related kinase 2 / O35942* / P51955* / Serine/threonine-protein kinase Nek2 *  / reaction / complex
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / complex / reaction
 ENSDARG00000074927 bub1bb / BUB1 mitotic checkpoint serine/threonine kinase Bb / BUB1B* / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / complex / reaction
 ENSDARG00000100741 cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*  / reaction / complex






 

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