ENSDARG00000007971


Danio rerio

Features
Gene ID: ENSDARG00000007971
  
Biological name :cks1b
  
Synonyms : CDC28 protein kinase regulatory subunit 1B / cks1b
  
Possible biological names infered from orthology : CDC28 protein kinase 1b, retrogene / Cks1brt / Cyclin-dependent kinases regulatory subunit 1 / P61024 / P61025
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 7835025
Gene end: 7838232
  
Corresponding Affymetrix probe sets: Dr.25182.2.S1_at (Zebrafish Array)   NM_001003593_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000003357
NCBI entrez gene - 445199     See in Manteia.
RefSeq - NM_001003593
RefSeq Peptide - NP_001003593
swissprot - Q6DEL8
ZFIN ID - ZDB-GENE-040801-112
Ensembl - ENSDARG00000007971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CKS1BENSGALG00000028664Gallus gallus
 CKS1BENSG00000173207Homo sapiens
 Cks1bENSMUSG00000028044Mus musculus
 Cks1brtENSMUSG00000062687Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CKS2 / zgc:86839 / P33552* / CDC28 protein kinase regulatory subunit 2*ENSDARG0000011708976
cks2 / CDC28 protein kinase regulatory subunit 2ENSDARG0000007141072


Protein motifs (from Interpro)
Interpro ID Name
 IPR000789  Cyclin-dependent kinase, regulatory subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IBA
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0061575 cyclin-dependent protein serine/threonine kinase activator activity IBA


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / reaction / complex
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / complex / reaction
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / complex / reaction
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / reaction / complex
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / complex / reaction






 

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