ENSMUSG00000028044


Mus musculus

Features
Gene ID: ENSMUSG00000028044
  
Biological name :Cks1b
  
Synonyms : Cks1b / Cyclin-dependent kinases regulatory subunit 1 / P61025
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 89415472
Gene end: 89418383
  
Corresponding Affymetrix probe sets: 10499639 (MoGene1.0st)   1416698_a_at (Mouse Genome 430 2.0 Array)   1448441_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138900
Ensembl peptide - ENSMUSP00000029679
Ensembl peptide - ENSMUSP00000103045
NCBI entrez gene - 54124     See in Manteia.
MGI - MGI:1889208
RefSeq - NM_016904
RefSeq Peptide - NP_058600
swissprot - D3YXP1
swissprot - P61025
swissprot - V9GWZ0
Ensembl - ENSMUSG00000028044
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cks1bENSDARG00000007971Danio rerio
 CKS1BENSGALG00000028664Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*ENSMUSG0000006268794
Cks2 / P56390 / Cyclin-dependent kinases regulatory subunit 2 / P33552* / CDC28 protein kinase regulatory subunit 2*ENSMUSG0000006224878


Protein motifs (from Interpro)
Interpro ID Name
 IPR000789  Cyclin-dependent kinase, regulatory subunit
 IPR036858  Cyclin-dependent kinase, regulatory subunit superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IGI
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0044772 mitotic cell cycle phase transition IGI
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IBA
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0061575 cyclin-dependent protein serine/threonine kinase activator activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

Allelic Composition: Cks1btm1Sir/Cks1b+,Tg(IghMyc)22Bri/?
Genetic Background: involves: C57BL * C57BL/6 * SJL

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Cks1btm1Sir/Cks1b+
Genetic Background: Not Specified

Allelic Composition: Cks1btm1Sir/Cks1b+,Tg(IghMyc)22Bri/?
Genetic Background: involves: C57BL * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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